A genomic incompatibility could explain why many kidney transplants fail, even when donors and recipients are thought to be well-matched, a new study from researchers at Columbia University Vagelos College of Physicians and Surgeons suggests. The genomic collision is a genetic incompatibility between kidney donor and recipient, causing the recipient to mount an immune attack… Read more

A whole-genome sequencing study of nearly 2,000 families has implicated mutations in promoter regions of the genome – regions that precede the start of a gene – in autism spectrum disorder. The study is the first genome-wide analysis to uncover a role for mutations in the noncoding portion of the genome in any human condition… Read more

A UCLA-led research team has pinpointed genetic processes involved in the neurodegeneration that occurs in dementia. This represents an important step on the path toward developing therapies that could slow or halt the course of the disease. The researchers discovered two major groups of genes involved in mutations that result in an overproduction of a… Read more

At the cutting edge of modern science, DNA sequencing promises to transform many aspects of human life. It’s already playing a significant role in law enforcement, as well as medical and historical research. But there’s a growing inequality in its impacts and in the chances of your genetic data being recorded – whether that’s by… Read more

“This is when I start feeling my age,” says Anne Corcoran. She’s a scientist at the Babraham Institute, a human biology research centre in Cambridge, UK. Corcoran leads a group that looks at how our genomes – the DNA coiled in almost every cell in our bodies – relate to our immune systems, and specifically… Read more