Overlooked MRI Signal May Aid Diagnosis Of Brain Conditions

A new technique that analyzes overlooked data from MRI scans reveals how many and which brain cells patients have — and shows where they’ve lost cells through injury or disease. The method eventually may lead to new ways to diagnose Alzheimer’s disease, multiple sclerosis, traumatic brain injury, autism, and other…Continue readingOverlooked MRI Signal May Aid Diagnosis Of Brain Conditions

Dopamine Neuron Enhancers Linked To Neuropsychiatric Disease

Using a new technique known as laser-capture RNA seq, that involves cutting out dopamine neurons from a human brain section with a laser, investigators from Brigham and Women’s Hospital and Harvard Medical School have cataloged more than 70,000 novel elements active in these brain cells. Dopamine neurons are located in…Continue readingDopamine Neuron Enhancers Linked To Neuropsychiatric Disease

Simple Blood Test Could Read People’s Internal Clock

In life, timing is everything. Your body’s internal clock – the circadian rhythm – regulates an enormous variety of processes: when you sleep and wake, when you’re hungry, when you’re most productive. Given its palpable effect on so much of our lives, it’s not surprising that it has an enormous…Continue readingSimple Blood Test Could Read People’s Internal Clock

Sox10 Gene Controls Triple-negative Breast Cancer Growth

The gene Sox10 directly controls the growth and invasion of a significant fraction of hard-to-treat triple-negative breast cancers, a team at the Salk Institute has found. Recently, the Salk lab led by Professor Geoffrey Wahl discovered that aggressive breast cancers return to a flexible, earlier state found in fetal breast…Continue readingSox10 Gene Controls Triple-negative Breast Cancer Growth

Genetic Variants Linked With Alzheimer’s Asymmetrical Neuron Loss

Genetic variants that promote the emergence of asymmetrical brain atrophy in Alzheimer’s patients have now been identified in a new study from Ludwig Maximilian University of Munich. In previous studies, Christian Wachinger, a neuroinformatics specialist at LMU, was able to show that, as dementia progresses, asymmetries develop in the brain…Continue readingGenetic Variants Linked With Alzheimer’s Asymmetrical Neuron Loss

Autism-associated CHD8 Required For Oligodendrocyte Development

CHD8, a gene already linked to a subset of people with autism spectrum disorder, is critical to healthy neuronal connections in the developing brain, new preclinical research shows. The work also shows the gene’s loss can harm those connections to help fuel the complex developmental condition. Scientists at Cincinnati Children’s…Continue readingAutism-associated CHD8 Required For Oligodendrocyte Development

Protein Networks Linked With Neurodevelopmental Disorders

150 proteins affecting cell activity and brain development have been identified by researchers at University of Southern California, which contribute to mental disorders, including schizophrenia, bipolar condition and depression. It is the first time that these molecules, which are associated with the disrupted-in-schizophrenia 1 (DISC1) protein linked to mental disorders,…Continue readingProtein Networks Linked With Neurodevelopmental Disorders