gene expression

A genetic network linked to autism has been uncovered by researchers at the University of Toronto, The findings will facilitate developing new therapies for this common neurological disorder. As part of a collaborative research program focusing on autism led by Benjamin Blencowe, a professor in the University of Toronto’s Donnelly Centre for Cellular and Biomolecular… Read more

Researchers at UCLA used single cell sequencing to look in real time at how head injury affects thousands of individual cells and genes simultaneously in mice. This approach could lead to precise treatments for traumatic brain injury (TBI). “Instead of clustering responses according to categories of cells in TBI, we can now see how individual… Read more

The protein Apolipoprotein E (ApoE) plays a central role in proper development of adult-born neurons in the hippocampus, new research from a group at Columbia University indicates. ApoE is one of the genes that regulate ongoing generation of neurons in the dentate gyrus of the hippocampus, a process known as adult neurogenesis. A variant of… Read more

A single episode of binge drinking can affect the gene that regulates sleep, leading to sleep disruption, a new study with mice shows. The findings may shed light on how sleep problems can contribute to alcoholism in humans. One in six adults in the United States binge drinks at least four times a month, according… Read more

Distinct genetic changes in the brain’s reward circuitry are associated with cocaine use, including first-time use, withdrawal, and re-exposure to the drug after prolonged withdrawal, a new study indicates. The findings represent important information on how cocaine addiction reprograms gene expression and provide insight into the molecular basis of cocaine addiction in unprecedented detail. In… Read more