Gene Expression Rhythms Are Disrupted In Schizophrenia-Affected Brains

mitosis
Rhythms in gene expression in the brain are highly disrupted in people with schizophrenia, according to a new University of Pittsburgh-led study. The findings also suggest that researchers studying schizophrenia-linked genes in the brain could have missed important clues that would help understand the disease. "Our study shows for the first time that there are …

Genomic Mechanism Regulates Smell Receptor Selection

smell
A genomic mechanism by which a finite number of genes can ultimately help distinguish a seemingly near-infinite number of scents has been identified by researchers from Columbia University. The human nose can distinguish one trillion different scents - an extraordinary feat that requires 10 million specialized nerve cells, or neurons, in the nose, and a …

Skin Myofibroblast Gene Expression Changes During Aging

Myofibroblast diversity
Differences in the cells that give skin its resilience and strength during wound repair may explain why individuals heal differently, according to a new Yale study. Fibroblasts, the cells that form the protein structure beneath the surface of the skin, were once thought to be fairly uniform in their function. However, the new study found …

CRISPR Helps Unravel Genetic Network Linked To Autism

autism network
A genetic network linked to autism has been uncovered by researchers at the University of Toronto, The findings will facilitate developing new therapies for this common neurological disorder. As part of a collaborative research program focusing on autism led by Benjamin Blencowe, a professor in the University of Toronto's Donnelly Centre for Cellular and Biomolecular …

Single Cell Sequencing Uncovers Potential Brain Injury Treatment Targets

Potential Brain Injury Treatment Targets
Researchers at UCLA used single cell sequencing to look in real time at how head injury affects thousands of individual cells and genes simultaneously in mice. This approach could lead to precise treatments for traumatic brain injury (TBI). "Instead of clustering responses according to categories of cells in TBI, we can now see how individual …

ApoE4 Impairs Dendritic Complexity In Adult Neurogenesis

ApoE-expressing astrocytes
The protein Apolipoprotein E (ApoE) plays a central role in proper development of adult-born neurons in the hippocampus, new research from a group at Columbia University indicates. ApoE is one of the genes that regulate ongoing generation of neurons in the dentate gyrus of the hippocampus, a process known as adult neurogenesis. A variant of …