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Cas12b Enzyme For Eukaryotic Cells Adds To The CRISPR Toolbox

A team that includes the scientist who first harnessed the revolutionary CRISPR-Cas9 and other systems for genome editing of eukaryotic organisms, including animals and plants, has engineered another CRISPR system, called Cas12b. The new system offers improved capabilities and options when compared to CRISPR-Cas9 systems. In a study published in Nature Communications, Feng Zhang and […]

New Viral-mediated Strategy for Genome Editing In The Brain

A new tool that, for the first time, allows precise genome editing in mature neurons, has been developed by researchers at the Max Planck Florida Institute for Neuroscience (MPFI). Genome editing technologies have revolutionized biomedical science, providing a fast and easy way to modify genes. However, the technique allowing scientists to carryout the most precise […]

Retinitis Pigmentosa: Restoring Visual Function With CRISPR/Cas9

Mutated optic rod photoreceptors have been reprogrammed, using the gene-editing tool CRISPR/Cas9, reversing cellular degeneration and restoring visual function in two mouse models of retinitis pigmentosa. The study was done by researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health, with colleagues in China. Retinitis […]

Genetic Circuits Target Cells For Boolean Logic And Arithmetic

A new platform offers a fast and more efficient way to target and program mammalian cells as genetic circuits, even complex ones. Wilson Wong, professor of biomedical engineering at Boston University, explains: “The problem synthetic biologists are trying to solve is how we ask cells to make decisions and try to design a strategy to […]