A microbial metabolite, Urolithin A, derived from a compound found in berries and pomegranates, can reduce and protect against inflammatory bowel disease (IBD), scientists at the University of Louisville have shown. Millions of people worldwide suffer from IBD in the form of either ulcerative colitis or Crohn’s disease, and few effective long-term treatments are available… Read more

People who had their appendix removed early in life had a lower risk of developing Parkinson’s disease decades later, researchers report. The finding represents a new clue that the tremor-inducing brain disease may get its start not in the brain but in the gut. A peek at surgically removed appendix tissue shows this tiny organ… Read more

Researchers in Australia have conducted the first population-based study of its kind and found that proton pump inhibitors (PPIs), a class of acid suppressants that many people take for heartburn, gastroesophageal reflux disease (GERD), and peptic ulcers, are associated with iron deficiency. Heartburn is a symptom of gastroesophageal reflux, which hydrochloric acid rising into the… Read more

Pluripotent stem cells have now been used to grow human esophageal organoids, scientists working to bioengineer the entire human gastrointestinal system in a laboratory report. The study is the latest advancement from researchers at the Cincinnati Children’s Center for Stem Cell and Organoid Medicine (CuSTOM). The center is developing new ways to study birth defects… Read more

Certain macrophages in the intestines of mice can survive for quite some time, scientists at KU Leuven, Belgium, report. Most importantly, these long-lived macrophages were found to be vital for the survival of the nerve cells of the gastrointestinal tract. This sheds new light on neurodegenerative conditions of the intestine, but also of the brain… Read more