epigenetics

Men in their child-bearing years should consider how marijuana use could impact their sperm and possibly the children they conceive during periods when they’ve been using the drug, new research from Duke Health suggests. As legal access to marijuana continues expanding across the U.S., more scientists are studying the effects of its active ingredient, tetrahydrocannabinol… Read more

A protein known as transcriptional enhancer factor TEF-1 (TEAD1) is an important regulator of tumor migration in glioblastoma, the most common brain tumor in adults, and deactivating this protein may stop tumor cells from migrating away from the main tumor mass, according to new research from the Icahn School of Medicine at Mount Sinai. The… Read more

Epigenetic changes that accompany glioblastoma progression and predict patient survival have been identified in a new study of more than 200 glioblastoma patients. The work, from the research group of Christoph Bock, principal investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, analyzed DNA methylation (which is the classical… Read more

Researchers from the University of Wisconsin–Madison have compared the whole genomes of children with very high-stress early lives to those of kids whose childhoods were relatively tranquil. They found scores of differences in how their genes function, differences that may point out avenues to better diagnosis and treatment of stress-related disorders. “We know that early… Read more

The absence of a protein called fragile X mental retardation protein (FMRP) can unbalance critical molecular processes within adult brain cells and lead to the neural and cognitive changes seen in fragile X syndrome, researchers at the University of Wisconsin–Madison report. Using animal models and chemical compounds, the researchers also showed that rebalancing the molecular… Read more