The definitive architecture of the mammalian body is established shortly after implantation of the embryo in the uterus. The antero-posterior, dorso-ventral and medio-lateral axes of the body become organized under the control of gene networks that coordinate the transcription of DNA in various regions of the embryo. Researchers from the University of Geneva (UNIGE), the… Read more

A specific biochemical signaling pathway contributes to noise canceling in the differentiation process of neural stem cells, Kanazawa University researchers report. Neural stem cells are self-renewing cells that play an important part in the development of the nervous system of animals during the embryonic stage. In biology, the physical differences between organisms of the same… Read more

During the development of the cerebral cortex, bioelectric properties help coordinate neuron diversity, new research from the University Of Geneva has found. The cerebral cortex is a highly developed brain region, which allows intellectual functions such as conscious perception, anticipation of events and language. These functions are mediated by specific sets of neuronal circuits. To… Read more

The disease mechanism for adult-onset progressive degenerative diseases begins much earlier than previously thought, a Northwestern Medicine study suggests. The findings are important since they raise the possibility that other adult-onset neurodegenerative diseases have their roots in early developmental defects, with implications for pathogenesis and treatment, according to senior author Puneet Opal, MD, PhD, professor… Read more

The human brain’s tiniest blood vessels can activate genes known to trigger spinal motor neurons, prompting the neurons to grow during early development, new research has revealed. The findings could provide insights into how amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders may develop. To make the discovery, investigators successfully re-created living tissues of the… Read more