drug discovery

A new system for keeping tissue viable for long-term study once transferred from an animal to a culture medium has been developed by researchers at the RIKEN Center for Biosystems Dynamics Research in Japan. The new system[1] uses a microfluidic device that can keep tissue from both drying out and from drowning in fluid. A… Read more

Common herbs, including lavender, fennel, and chamomile, have a long history as folk medicines used to lower blood pressure. New research explains the molecular mechanisms at work. The study[1] illustrates how many of the known traditional botanical plants used to lower blood pressure activate a specific potassium channel (KCNQ5) in blood vessels. “We found KCNQ5… Read more

Damage to myelin caused by inflammatory oligodendrocyte cell destruction combined with axon degeneration are two of the signs of multiple sclerosis (MS). Most of the available medications for MS are approved for relapsing–remitting (RR) MS, for which they reduce relapse rate, MRI measures of inflammation, and the accumulation of disability. But these medications are of… Read more

One of the most common brain cancers in children, Sonic Hedgehog (SHH) medulloblastoma, also is one of the more survivable for most kids. Unfortunately, for a subset of patients the cancer resists treatment and relapses with a vengeance to then turn deadly. Researchers at Cincinnati Children’s Hospital Medical Center used a powerful new computer-assisted technology… Read more

A novel formulation of multiple amino acids hinders the replication of Zika virus by up to 90% in human and non-human primate cells, a new study[1] indicates. Researchers tested a unique composition of three free-form amino acids (FFAAP) — cystine, glycine, and glutamate, as well as a minute amount of selenium — that was previously… Read more