drug discovery

A molecular switch can turn on a substance in animals that repairs neurological damage in disorders such as multiple sclerosis (MS), Mayo Clinic researchers have discovered. The early research in animal models could advance an already approved Food and Drug Administration therapy and also could lead to new strategies for treating diseases of the central… Read more

A class of antibiotics called aminoglycosides could be a promising treatment for frontotemporal dementia, researchers at the University of Kentucky’s College of Medicine have found. Frontotemporal dementia is the second-most common dementia after Alzheimer’s disease and the most common type of early onset dementia. It typically begins between ages 40 and 65 and affects the… Read more

A receptor believed to be linked to negative moods, in a part of the brain that is little-understood, has been uncovered by an international research team. The discovery[1] could lead to more targeted medications. The pea-sized receptor was found in a little-studied region in the center of the human brain, the medial habenula. “The function… Read more

Anti-inflammatory agents, such as aspirin/paracetamol, statins, and antibiotics, can safely and effectively curb the symptoms of major depression, finds a newly published meta-analysis of the available evidence. And the effects are even stronger when these agents are added on to standard antidepressant treatment, the results show. Around a third of people who are clinically depressed… Read more

A new system for keeping tissue viable for long-term study once transferred from an animal to a culture medium has been developed by researchers at the RIKEN Center for Biosystems Dynamics Research in Japan. The new system[1] uses a microfluidic device that can keep tissue from both drying out and from drowning in fluid. A… Read more