drug discovery

People who develop Parkinson’s disease before age 50 may have been born with disordered brain cells that went undetected for decades, research from Cedars-Sinai Medical Center suggests. The study reports on a drug that potentially might help correct these disease processes. Although most Parkinson’s patients are 60 or older when they are diagnosed, about 10%… Read more

A molecular switch can turn on a substance in animals that repairs neurological damage in disorders such as multiple sclerosis (MS), Mayo Clinic researchers have discovered. The early research in animal models could advance an already approved Food and Drug Administration therapy and also could lead to new strategies for treating diseases of the central… Read more

A class of antibiotics called aminoglycosides could be a promising treatment for frontotemporal dementia, researchers at the University of Kentucky’s College of Medicine have found. Frontotemporal dementia is the second-most common dementia after Alzheimer’s disease and the most common type of early onset dementia. It typically begins between ages 40 and 65 and affects the… Read more

A receptor believed to be linked to negative moods, in a part of the brain that is little-understood, has been uncovered by an international research team. The discovery[1] could lead to more targeted medications. The pea-sized receptor was found in a little-studied region in the center of the human brain, the medial habenula. “The function… Read more

Anti-inflammatory agents, such as aspirin/paracetamol, statins, and antibiotics, can safely and effectively curb the symptoms of major depression, finds a newly published meta-analysis of the available evidence. And the effects are even stronger when these agents are added on to standard antidepressant treatment, the results show. Around a third of people who are clinically depressed… Read more