Brain Tumors Remodel Synapses To Promote Growth

New evidence that glioma, a lethal form of brain cancer, alters the activity of neighboring neurons, accelerating a vicious cycle that drives tumor-associated epilepsy and tumor progression, has been found by scientists at Baylor College of Medicine. The findings[1] show that several variants of the PIK3CA gene drive tumor progression…Continue readingBrain Tumors Remodel Synapses To Promote Growth

Distinct Transitional States Of Cortex Glial Progenitors Uncovered

A molecular driver of the highly aggressive, deadly, and treatment-resistant brain cancer glioblastoma has been uncovered by scientists, using cell-by-cell genetic analyses of developing brain tissues in neonatal mice and laboratory models of brain cancer. The study identified a subpopulation of cells critical to glioblastoma formation – the early primitive…Continue readingDistinct Transitional States Of Cortex Glial Progenitors Uncovered

Glioblastoma DNA Methylation Landscape Mapped

Epigenetic changes that accompany glioblastoma progression and predict patient survival have been identified in a new study of more than 200 glioblastoma patients. The work, from the research group of Christoph Bock, principal investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, analyzed DNA…Continue readingGlioblastoma DNA Methylation Landscape Mapped

Combination Immunotherapy Shrinks Untreated Melanoma Brain Metastases

Combination immunotherapy shrank melanoma that has spread to the brain in more than half of the patients in a clinical trial led by an investigator at The University of Texas MD Anderson Cancer Center. Of 94 patients in the single-arm study combining checkpoint inhibitors ipilimumab and nivolumab, at a minimum…Continue readingCombination Immunotherapy Shrinks Untreated Melanoma Brain Metastases

Telomerase-positive Pediatric Brain Tumors: Possible New Treatment Method

An experimental molecular therapy in has been used in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer. The researchers now propose advancing the treatment to clinical testing in children. The small molecule 6-thio-2’deoxyguanosine (6-thio-dG) was tested in brain cancer stem cells derived from tumor cells…Continue readingTelomerase-positive Pediatric Brain Tumors: Possible New Treatment Method

FOXM1: Aggressive Meningiomas Linked To Single Gene

A common genetic driver of aggressive meningiomas has been uncovered by UC San Francisco scientists. The finding could help clinicians detect such dangerous cancers earlier and lead to new therapies aimed at curing these difficult-to-treat tumors. Meningiomas are tumors that grow from the layer of tissue that surrounds the brain…Continue readingFOXM1: Aggressive Meningiomas Linked To Single Gene

Dendritic Cell Immunotherapy Gives Hope For Beating Brain Cancer

High-grade glioma is the most aggressive form of brain cancer. Despite improvements in surgical procedures, chemotherapy, and radiotherapy, this type of brain tumour is still notoriously hard to treat: less than 10% of patients survive beyond five years. Researchers from KU Leuven, Belgium, have now shown that next-generation cell-based immunotherapy…Continue readingDendritic Cell Immunotherapy Gives Hope For Beating Brain Cancer