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Distinct Transitional States Of Cortex Glial Progenitors Uncovered

A molecular driver of the highly aggressive, deadly, and treatment-resistant brain cancer glioblastoma has been uncovered by scientists, using cell-by-cell genetic analyses of developing brain tissues in neonatal mice and laboratory models of brain cancer. The study identified a subpopulation of cells critical to glioblastoma formation – the early primitive progenitor cells of oligodendrocyte brain […]

Glioblastoma DNA Methylation Landscape Mapped

Epigenetic changes that accompany glioblastoma progression and predict patient survival have been identified in a new study of more than 200 glioblastoma patients. The work, from the research group of Christoph Bock, principal investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, analyzed DNA methylation (which is the classical […]

Combination Immunotherapy Shrinks Untreated Melanoma Brain Metastases

Combination immunotherapy shrank melanoma that has spread to the brain in more than half of the patients in a clinical trial led by an investigator at The University of Texas MD Anderson Cancer Center. Of 94 patients in the single-arm study combining checkpoint inhibitors ipilimumab and nivolumab, at a minimum follow-up of nine months and […]

Telomerase-positive Pediatric Brain Tumors: Possible New Treatment Method

An experimental molecular therapy in has been used in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer. The researchers now propose advancing the treatment to clinical testing in children. The small molecule 6-thio-2’deoxyguanosine (6-thio-dG) was tested in brain cancer stem cells derived from tumor cells donated by patients. Researchers also […]

FOXM1: Aggressive Meningiomas Linked To Single Gene

A common genetic driver of aggressive meningiomas has been uncovered by UC San Francisco scientists. The finding could help clinicians detect such dangerous cancers earlier and lead to new therapies aimed at curing these difficult-to-treat tumors. Meningiomas are tumors that grow from the layer of tissue that surrounds the brain and spinal cord and are […]