A key role for cellular senescence, particularly in astrocytes, in excitotoxicity, which may lead to neurodegeneration, is suggested in research from the Buck Institute. “This study gets to the underlying mechanisms that drive the toxicity. We have identified targets that may be of more use in drug development,” said senior author and Buck professor Judith… Read more

A sustained state of vigilance will generate a different type of memory than a momentary startle, and these differences are linked to distinct signaling molecules in the brains of mice. Researchers at the RIKEN Center for Brain Science (CBS) have visualized these dynamics in the living mouse brain for the first time, observing fast and… Read more

Previous research into brain damage caused by the Zika virus shows the virus’s preference for a particular neural cell: the astrocyte. However, few studies have sought to identify the infection effects on these cells, as well as their association with developmental alterations, including brain malformations and microcephaly. Now, new work explores the virus’s consequences on… Read more

Astrocytes, previously thought to provide mainly nourishment and housekeeping functions for neurons, may play a key role in the regulation of attention deficit disorder and hyperactivity, a new UCLA study suggests. “Unmasking how astrocytes contribute to brain function is one of the most important open questions in neuroscience. We have made some progress, but our… Read more

Estrogen in the brain is important to keep neurons communicating and memories being made, new research indicates. Neurons in both males and females make estrogen and the scientists have shown that when they don’t, their brains have significantly less dense spines and synapses — both key communication points for neurons — in the biggest part… Read more