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Human Organ Chip Models Lung Cancer Growth & Drug Response

Human orthotopic lung cancer models have been developed by a team at the Wyss Institute, using two microfluidic devices. For today’s cancer researchers, generating human tumours in mice by injecting cancer cell lines under the skin does not recreate how tumours normally emerge and spread to specific organs in the human body, nor how they […]

3D Bioprinting Could Be The Next Pharmaceutical Revolution

Body organs such as kidneys, livers and hearts are incredibly complex tissues. Each is made up of many different cell types, plus other components that give the organs their structure and allow them to function as we need them to. For 3D printed organs to work, they must mimic what happens naturally – both in […]

Capillary-like Networks Expand Mini-brains Research Potential

Three dimensional cultures of neural cells that model basic properties of the brain produce networks of capillaries, Brown University research shows. The networks of capillaries within the little balls of nervous system cells could enable new kinds of large-scale lab investigations into diseases, such as stroke or concussion, where the interaction between the brain and […]

HuMiX Gut On A Chip Mimics Microbiome Drug Reactions

A new artificial gut will allow scientists to see how cells from individuals respond to certain drugs or immune therapies, allowing them to formulate personalized treatments. With the new technology, researchers can analyze the complex interactions between human cells and the microbial ecosystems of the gut, predicting their effects on health or disease onset, and […]

Decellularizing And Rebuilding Donated Hearts With Recipients’ Own Cells

Massachusetts General Hospital researchers have taken some initial steps toward the creation of bioengineered human hearts using donor hearts stripped of components that would generate an immune response and cardiac muscle cells generated from induced pluripotent stem cells (iPSCs), which could come from a potential recipient. Lead author Jacques Guyette, PhD, of the Massachusetts General […]