Osteoarthritis, a disease that causes severe joint pain, affects more than 20 million people in the United States. Some drug treatments can help alleviate the pain, but there are no treatments that can reverse or slow the cartilage breakdown associated with the disease. In an advance that could improve the treatment options available for osteoarthritis… Read more

Researchers have uncovered a new mechanism of bone erosion and a possible biomarker for rheumatoid arthritis. The group is the first to demonstrate that immune cells, called B cells, contribute directly to the breakdown of bone in RA by producing a signaling molecule called RANKL. Jennifer Anolik, professor of medicine at the University of Rochester… Read more

Experimentally-induced rheumatoid arthritis in serotonin-deficient mice is worse than the same disease reported in no-deficient mice, a recent study shows. Additionally, it was found that some effects of rheumatoid arthritis (RA) can be reduced by serotonin or its agonists (compounds that activate serotonin receptors). This is the first time, serotonin (5-hydroxytryptamine, 5-HT) has been directly… Read more

Osteoarthritis is the most common musculoskeleton disease. It is caused by the loss of articular cartilage and subchondral tissue, which causes pain, stiffness and a loss of mobility in joints. The protein CCN4 positively regulates the generation of cartilage matrix, which are depleted in osteoarthritis, new research shows. Adult cartilage does not readily regenerate, and… Read more

Researchers at Washington State University in Spokane have identified a potential new approach to combating the joint pain, inflammation and tissue damage caused by rheumatoid arthritis. Rheumatoid arthritis is a debilitating autoimmune disorder that mostly affects the small joints of the hands and feet. It causes painful swelling that progresses into cartilage damage, bone erosion… Read more