The proportion of individuals aged over 65 on antidepressants has more than doubled in the past two decades, according to new research led by the University of East Anglia. Despite a rise in antidepressant use, there was little change in the number of older people diagnosed with depression. The findings are based on the Cognitive… Read more

A neurosteroids approach to alleviate depression, using CRISPR technology, is being investigated by researchers at Washington University School of Medicine in St. Louis and Sage Therapeutics in Boston. Most antidepressant drugs target serotonin receptors, aiming to boost serotonin, a chemical thought to regulate mood and social behavior. Using gene editing, the scientists have been able… Read more

Stimulation of serotonin neurons boosts the rate of learning in mice, an international team from the Champalimaud Centre for the Unknown (CCU), in Portugal, and the University College London (UCL) in the U.K. has found. Serotonin is a monoamine neurotransmitter that nerve cells use to communicate with each other, and its effects on behavior are… Read more

The Daily Telegraph reports that “Antidepressants could double the risk of feelings that could lead to suicide, according to a new study which has triggered furious rows.” Critics have attacked the study as “fatally flawed” because researchers extrapolated certain side effects, such as anxiety, as being a risk factor for suicide. Researchers carried out an analysis… Read more

Most antidepressants prescribed for children and teenagers with major depression are ineffective, and could even be unsafe, a major review shows. The comprehensive review found that of 14 antidepressant drugs, only fluoxetine (Prozac) was more effective at relieving the symptoms of depression than a placebo. Taking venlafaxine (Effexor) was linked with an increased risk of… Read more