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Alzheimer’s: Microglia Have Key Role In Proliferation Of Tau Pathologies

The link between amyloid beta and tau may lie in the brain’s immune cells that hem in clumps of amyloid, researchers at Washington University School of Medicine in St. Louis have found. If the immune cells falter, amyloid clumps, or plaques, injure nearby neurons and create a toxic environment that accelerates the formation and spread […]

Viral Protein Corona Linked To Alzheimer’s Amyloid Aggregation

Viruses interact with proteins in the biological fluids of their host which results in a layer of proteins on the viral surface, new research from Stockholm University and Karolinska Institutet shows. This coat of proteins makes the virus more infectious and facilitates the formation of plaques characteristic of neurodegenerative diseases such as Alzheimer’s disease. “Imagine […]

Alzheimer’s Disease As A Double-Prion Disorder

Two proteins involved in Alzheimer’s disease pathology act as prions — misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape — new research from UC San Francisco indicates. Using novel laboratory tests, the researchers were able to detect and measure specific, self-propagating prion forms of […]

Alzheimer’s Psychiatric Symptoms Linked To Early Brain Pathology

The earliest stages of the brain degeneration associated with Alzheimer’s disease (AD) are linked to neuropsychiatric symptoms including anxiety, depression, loss of appetite, and sleep disturbances, a study from UC San Francisco researchers, in collaboration with the unique Brazilian Biobank for Aging Studies (BBAS) at the University of São Paulo, has shown. The findings could […]

SynuClean-D Can Revert Neurodegeneration Caused By Parkinson’s

The small SynuClean-D molecule interrupts the formation of the alpha-synuclein amyloid fibres responsible for the onset of Parkinson’s disease, and reverts the neurodegeneration caused by the disease, work led by researchers at the Institute of Biotechnology and Biomedicine (IBB) of the Universitat Autònoma de Barcelona has found. After analysing over 14,000 molecules, they identified the […]