Applying a low voltage current can bring different areas of the brain in sync with one another, enabling people to perform better on tasks involving working memory, researchers at Imperial College London have found. The approach, scientists hope, could one day be used to bypass damaged areas of the brain and relay signals in people with traumatic brain injury, stroke or epilepsy.
The brain is constantly chattering to itself, and the activity can be seen as brainwaves oscillating at different frequencies and different regions keeping a steady ‘beat’.
In a small study, the Imperial team found that applying a weak electrical current through the scalp helped to align different parts of the brain, synchronising these brain waves and enabling them to keep the same beat.
Think To The Rhythm
Dr Ines Ribeiro Violante, a neuroscientist in the Department of Medicine at Imperial, who led the research, said:
“What we observed is that people performed better when the two waves had the same rhythm and at the same time."
The team used a technique called transcranial alternating current stimulation (TACS) to manipulate the brain’s regular rhythm. They found that buzzing the brain with electricity could give a performance boost to the same memory processes used when people try to remember names at a party, telephone numbers, or even a short grocery list.
TCAS was used to target two brain regions - the middle frontal gyrus and the inferior parietal lobule - which are known to be involved in working memory.
[caption id=“attachment_88927” align=“aligncenter” width=“680”] The scans show that stimulation ‘in beat’ increases brain activity in the regions involved in task performance. On the other hand, stimulation ‘out of beat’showed activity in regions usually associated with resting. Credit: Ines Violante[/caption]
Ten volunteers were asked to carry out a set of memory tasks of increasing difficulty while receiving theta frequency stimulation to the two brain regions at slightly different times (unsynchronised), at the same time (synchronous), or only a quick burst (sham) to give the impression of receiving full treatment.
Testing Working Memory
In the working memory experiments, participants looked at a screen on which numbers flashed up and had to remember if a number was the same as the previous, or in the case of the harder trial, if it the current number matched that of two-numbers previous.
Results showed that when the brain regions were stimulated in sync, reaction times on the memory tasks improved, especially on the harder of the tasks requiring volunteers to hold two strings of numbers in their minds.
“The classic behavior is to do slower on the harder cognitive task, but people performed faster with synchronised stimulation and as fast as on the simpler task,” said Dr Violante.
Previous studies have shown that brain stimulation with electromagnetic waves or electrical current can have an effect on brain activity, the field has remained controversial due to a lack of reproducibility.
But using functional MRI to image the brain enabled the team to show changes in activity occurring during stimulation, with the electrical current potentially modulating the flow of information.
“We can use TACS to manipulate the activity of key brain networks and we can see what’s happening with fMRI,” explained Dr Violante. “The results show that when the stimulation was in sync, there was an increase in activity in those regions involved in the task. When it was out of sync the opposite effect was seen."
Restoring Lost Skills
However, one of the major hurdles for making such a treatment widely available is the individual nature of people’s brains. Not only do the electrodes have to get the right frequency, but target it to the right part of the brain and get the beat in time.
Dr Violante added:
“We use a very cheap technique, and that’s one of the advantages we hope it will bring if it’s translatable to the clinic. The next step is to see if the brain stimulation works in patients with brain injury, in combination with brain imaging, where patients have lesions which impair long range communication in their brains."
Professor David Sharp, a neurologist in Imperial’s Department of Medicine and senior author on the paper, added:
“We are very excited about the potential of brain stimulation to treat patients. I work with patients who often have major problems with working memory after their head injuries, so it would be great to have a way to enhance our current treatments, which may not always work for them. Our next step is to try the approach out in our patients and we will see whether combining it with cognitive training can restore lost skills."
Ines R Violante et al Externally induced frontoparietal synchronization modulates network dynamics and enhances working memory performance eLife (2017). DOI: 10.7554/eLife.22001