Smokers who succeed in quitting might actually be hardwired for success, suggests a new study from Duke University Medical Center.

The study showed greater connectivity among certain brain regions in people who were able quit smoking compared to those who tried and failed.

Researchers analyzed MRI scans of 85 people taken one month before they attempted to quit. All participants stopped smoking and the researchers tracked their progress for 10 weeks.

Forty-one participants relapsed.

Looking back at the brain scans of the 44 smokers who quit successfully, the researchers found they had something in common before they stopped smoking:

Better coordinated activity between the insula, home to urges and cravings, and the somatosensory cortex, a part of the brain that is central to our sense of touch and motor control.

Cigarette Cravings

Lead author Merideth Addicott, Ph.D., assistant professor at Duke, said:

“Simply put, the insula is sending messages to other parts of the brain that then make the decision to pick up a cigarette or not."

The insula, a large region in the cerebral cortex, has been the subject of many smoking cessation studies that show this area of the brain is active when smokers are craving cigarettes, said Joseph McClernon, Ph.D., associate professor at Duke and the study’s senior author.

Other studies have found that smokers who suffer damage to the insula appear to spontaneously lose interest in smoking.

“There’s a general agreement in the field that the insula is a key structure with respect to smoking and that we need to develop cessation interventions that specifically modulate insula function,” McClernon said. “But in what ways do we modulate it, and in whom? Our data provides some evidence on both of those fronts, and suggests that targeting connectivity between insula and somatosensory cortex could be a good strategy."

Neurofeedback and transcranial magnetic stimulation, used to improve depression, are two treatments that modulate brain activity. With the findings in this study, researchers now have more information on where to further investigate, McClernon said.

“We have provided a blueprint,” McClernon said. “If we can increase connectivity in smokers to look more like those who quit successfully, that would be a place to start. We also need more research to understand what it is exactly about greater connectivity between these regions that increases the odds of success."


Merideth A Addicott, Maggie M Sweitzer, Brett Froeliger, Jed E Rose, Francis J McClernon. Increased Functional Connectivity in an Insula-Based Network is Associated with Improved Smoking Cessation Outcomes. Neuropsychopharmacology, 2015; DOI: 10.1038/npp.2015.114

Photo shows activity in the brain, illustrated layer by layer. The colored regions represent the average functional connectivity with the posterior portion of the insula, an area of the brain linked to cigarette cravings in smokers. The top row represents the average connectivity among 44 study participants who successfully quit smoking, versus the average functional connectivity for 41 participants who relapsed, shown on the bottom row. A Duke Medicine study shows there is more connectivity between the insula and the somatosensory cortex among the smokers who quit compared to those who relapsed. Credit: Duke Medicine /flickr

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