Learning capabilities are limited during slow wave sleep, a group of researchers in Belgium reports. Using magnetoencephalography (MEG), they showed that while the brain is still able to perceive sounds during sleep, it is unable to group these sounds according to their organisation in a sequence.

Hypnopedia, or the ability to learn during sleep, was popularized in the 1960s via the dystopian Brave New World by Aldous Huxley, in which individuals are conditioned to their future tasks during sleep. This concept has been progressively abandoned due to a lack of reliable scientific evidence supporting in-sleep learning abilities.

Recently, however, a few studies have shown that the acquisition of elementary associations such as stimulus-reflex response is possible during sleep, both in humans and in animals. Nevertheless, it is not clear if sleep allows for more sophisticated forms of learning.

Frequency-tagged Responses

A new study by researchers from the Université libre de Bruxelles Neuroscience Institute (UNI) shows that while the brain is able to continue perceiving sounds during sleep, the ability to group these sounds according to their organization in a sequence is only active during wakefulness, and completely disappears during sleep.

Juliane Farthouat, while a research fellow of the FNRS under the direction of Philippe Peigneux, professor at the Faculty of Psychological Science and Education at Université libre de Bruxelles, used MEG to record the cerebral activity mirroring the statistical learning of series of sounds, both during slow wave sleep (a part of sleep during which brain activity is highly synchronized) and during wakefulness.

During sleep, 21 participants were exposed to fast flows of pure sounds, either randomly organized or structured in such a way that the auditory stream could be statistically grouped into sets of three elements. During sleep, brain MEG responses demonstrated preserved detection of isolated sounds, but no response reflecting statistical clustering.

[caption id="attachment_96881” align="aligncenter” width="680”]MEG frequency-tagged responses during NREM sleep for tones (5.505 Hz; top) and tritones (1.835 Hz; bottom) in STAT and RDM streams, averaged across participants (n = 9). MEG frequency-tagged responses during NREM sleep for tones (5.505 Hz; top) and tritones (1.835 Hz; bottom) in STAT and RDM streams, averaged across participants (n = 9).
Credit: Juliane Farthouat et al, CC-BY[/caption]

During wakefulness, however, all participants presented brain MEG responses reflecting the grouping of sounds into sets of three elements.

The results of this study suggest intrinsic limitations in de novo learning during slow wave NREM sleep that might confine the sleeping brain’s learning capabilities to simple, elementary associations.

Funding for the work came from the Belgian National Fund for Scientific Research (FRS-FNRS).

Juliane Farthouat, Anne Atas, Vincent Wens, Xavier De Tiege & Philippe Peigneux Lack of frequency-tagged magnetic responses suggests statistical regularities remain undetected during NREM sleep Scientific Reports volume 8, Article number: 11719

Top Image: Tritone-related frequency (1.835 Hz) tagging at wake in participants exposed (top) or not (bottom) to the STAT streams in sleep during the prior nap. (Left) Topographies of tritone-related SNR for STAT and RDM (and significant differences STAT - RDM; p < 0.001) in left and right temporal sensors of interests (white dots). (Right) Tritone-related SNR averaged within SOIs for RDM and STAT streams. Group and Group by Stream type interaction effects are non-significant (all ps > 0.4). Credit: Juliane Farthouat et al, CC-BY

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