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Proton Pump Inhibitor Drugs Can Trigger Allergies

ppi allergies action

Stomach-protecting drugs, especially so-called proton pump inhibitors or PPIs, correlate with subsequent prescriptions for anti-allergy medication, an Austrian study shows.

Using quantitative prescribing data from Austria, the study, conducted by MedUni Vienna in collaboration with the Austrian Social Insurance Institutions, validates the finding of previous epidemiological and experimental studies that stomach-protecting drugs can intensify or even trigger allergies.

The risk of an allergic reaction to allergens that requires anti-allergy treatment is doubled or even tripled.

Gastric Acid Inhibitors

Gastric acid inhibitors reduce the production of gastric acid, relieve heartburn and promote healing of any damaged gastric mucosa. They are frequently prescribed in support of drug therapies to prevent stomach problems or to counteract bloating. They are often the drug of choice for stress responses leading to reflux (heartburn).

The study analyzed prescriptions of anti-allergy medication (antihistamines, allergen immunotherapies) to people who had previously had prescriptions for stomach protectors from the years 2009 to 2013. The data for this quantitative study were primarily provided by all the Austrian Social Insurance Institutions. The correlation was striking.

“People who take stomach-protecting medication such as PPIs double or even triple their risk of developing allergic symptoms that require treatment,”

explains first author Galateja Jordakieva.

Gastric acid fulfills an important function in the digestive tract. The acid-dependent enzymes contained in it break down proteins in the food and take them for further processing.

Microbiome Changes

Gastric acid also acts as a barrier against bacteria and other pathogens. If these functions are diminished because of inhibited gastric acid production, allergens can find their way into the gut unprocessed. This can trigger allergies or aggravate the symptoms of people with pre-existing allergies.

“So-called ‘stomach protectors’ should not be used for any longer than necessary. They prevent protein digestion, change the microbiome in the gastro-intestinal tract and increase the risk of allergic reactions. As soon as they have fulfilled their prescribed medical function, they should be stopped as quickly as possible,”

warns principal investigator Erika Jensen-Jarolim.

Additionally, gastric acid inhibitors only treat the symptoms and not the cause of a complaint.

“Treating doctors should therefore ensure that such drugs are taken for the shortest possible time. Where they are used to treat stress symptoms such as heartburn, it is therefore better to make a lifestyle change or address one’s work-life balance,”

adds Jensen-Jarolim.

Galateja Jordakieva, Michael Kundi, Eva Untersmayr, Isabella Pali-Schöll, Berthold Reichardt & Erika Jensen-Jarolim
Country-wide medical records infer increased allergy risk of gastric acid inhibition
Nature Communications, volume 10, Article number: 3298 (2019)

Image: Galateja Jordakieva et al. CC-BY