What Is Gemtuzumab Ozogamicin?

Gemtuzumab ozogamicin (brand name Mylotarg), is an antibody-drug conjugate used to treat acute myeloid leukemia. Gemtuzumab is a monoclonal antibody to CD33 linked to a cytotoxic agent from the class of calicheamicins. CD33 is expressed in most leukemic blast cells but also in normal hematopoietic cells, the intensity diminishing with maturation of stem cells. Mylotarg…

Bcl-2 Regulator Protein

B-cell-lymphoma-2 (Bcl-2) is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. It was the first apoptosis regulator identified in any organism1. Bcl-2 is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and…

LSL60101 Reduces Cognitive Deficit In Neurodegeneration

The compound LSL60101 improved cognitive deficit and biomarkers related to Alzheimer’s disease in studies carried out with mice. The work is described in a paper1 detailing the synthesis of a new family of compounds with high affinity and selectivity for imidazoline I2 receptors, altered in the brain of patients with Alzheimer’s. The synthesis pathway of…

Why Even Smart People Can Make Bad Decisions

Intelligence and good decision-making don’t always go together. Even the smartest people are capable of making some pretty foolish decisions. Decision-making is another one of those things that should be taught in schools. It would probably prove to be a more useful skill than precalculus in the typical day of most people. It only takes…

What Is The Subventricular Zone?

The subventricular zone is a region situated on the outside wall of each lateral ventricle of the vertebrate brain. It is present in both the embryonic and adult brain. In embryonic life, the subventricular zone (SVZ) refers to a secondary proliferative zone containing neural progenitor cells, which divide to produce neurons in the process of…

Adaptive Brain Response To Stress Absent In People With Depression

A novel biomarker indicating resilience to chronic stress has been found by researchers. This biomarker is largely absent in people suffering from major depressive disorder, and this absence is further associated with pessimism in daily life, their new study1 finds. To our knowledge, this is the first work to show that glutamate in the human…

Who Discovered Neurofibromatosis

Neurofibromatosis type 1 (NF1), formerly called von Recklinghausen disease, is a common neurogenetic condition. Descriptions in art and literature of what is thought to be the condition go back as far back as 1500 BC. In 1882 the disease entity was fully recognized when the German pathologist Frederick von Recklinghausen published his monograph “On Multiple…

HDAC6 Inhibition A Potential New Migraine Treatment Approach

By identifying a possible novel cellular mechanism for migraines, researchers may have also found a new way to treat chronic migraine. The goal of the research1 was to find a new mechanism of chronic migraine and propose a cellular pathway for migraine therapies. Senior author Amynah Pradhan is associate professor of psychiatry at the University…