What Is The Subventricular Zone?

The subventricular zone is a region situated on the outside wall of each lateral ventricle of the vertebrate brain. It is present in both the embryonic and adult brain. In embryonic life, the subventricular zone (SVZ) refers to a secondary proliferative zone containing neural progenitor cells, which divide to produce neurons in the process of neurogenesis. The primary neural stem cells of the brain and spinal cord, termed radial glial cells, instead reside in the ventricular zone (VZ) (so-called because the VZ lines the inside of the developing ventricles).

Adaptive Brain Response To Stress Absent In People With Depression

A novel biomarker indicating resilience to chronic stress has been found by researchers. This biomarker is largely absent in people suffering from major depressive disorder, and this absence is further associated with pessimism in daily life, their new study1 finds. To our knowledge, this is the first work to show that glutamate in the human medial prefrontal cortex shows an adaptive habituation to a new stressful experience if someone has recently experienced a lot of stress.

Who Discovered Neurofibromatosis

Neurofibromatosis type 1 (NF1), formerly called von Recklinghausen disease, is a common neurogenetic condition. Descriptions in art and literature of what is thought to be the condition go back as far back as 1500 BC. In 1882 the disease entity was fully recognized when the German pathologist Frederick von Recklinghausen published his monograph “On Multiple Fibromas of the Skin and Their Relationship to Multiple Neuromas”1, in which he described the disease as well as the origin of skin tumors.

HDAC6 Inhibition A Potential New Migraine Treatment Approach

By identifying a possible novel cellular mechanism for migraines, researchers may have also found a new way to treat chronic migraine. The goal of the research1 was to find a new mechanism of chronic migraine and propose a cellular pathway for migraine therapies. Senior author Amynah Pradhan is associate professor of psychiatry at the University of Illinois Chicago. He explained that the dynamic process of routing and rerouting connections among nerve cells, called neural plasticity, is critical to both the causes and cures for disorders of the central nervous system such as depression, chronic pain, and addiction.

MAIT Cell Response May Explain Women’s Lower Severe COVID-19 Rate

Women suffer severe COVID-19 at around half the rate as men, but the reason for this has been unclear. Now, research1 has found that women have different levels of mucosal associated invariant T cells, and these immune cells amass in the lungs, poised to attack the COVID virus. Better armed with these specialized immune cells, women appear to be more equipped to fight some of the most severe impacts of COVID-19, notably the respiratory infections that can become life-threatening,

Staufen1: Protein Is Linked To Several Neurodegenerative Disorders

Staufen1, a protein that accumulates in the brains of patients with certain neurological conditions, is linked to amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, along with other neurological disorders, including Alzheimer’s, Parkinson’s, and Huntington’s disease, University of Utah Health scientists report. Credit: Unsplash/CC0 The findings1 connect Staufen1 to the emerging concept that neurodegenerative diseases are linked to malfunctions in the way cells cope with cellular stress. These results, based on laboratory studies of human tissue and mouse models, suggest that targeting Staufen1 could eventually lead to therapeutic interventions for a number of these disorders.

Blood Biomarkers For Mood Disorders Offer Precision-medicine Approach

An extensive push to identify and validate blood biomarkers for mood disorders has resulted in a blood test, composed of RNA biomarkers, that can distinguish how severe a patient’s depression is. The test also can predict their risk of severe depression in the future, and their risk of future bipolar disorder, or manic-depressive illness, as well as informs tailored medication choices for patients. The work1 builds on previous research into blood biomarkers2 that track suicidality as well as pain, post-traumatic stress disorder, and Alzheimer’s disease3.

Neural Substrates of Anhedonia In Frontotemporal Dementia Identified

People with early-onset dementia are often misdiagnosed as having depression. Research has now identified what may actually be happening in such cases: a profound loss of ability to experience pleasure. The loss is related to degeneration of ‘hedonic hotspots’ in the brain where pleasure mechanisms are concentrated, University of Sydney-led research1 shows. The study revealed marked degeneration, or atrophy, of grey matter in frontal and striatal areas of the brain related to diminished reward-seeking, in patients with frontotemporal dementia (FTD).