A nap during the day won’t give you relief from a sleepless night, according to a study from Michigan State University’s Sleep and Learning Lab1. We are interested in understanding cognitive deficits associated with sleep deprivation. In this study, we wanted to know if a short nap during the deprivation period would mitigate these deficits. We found that short naps of 30 or 60 minutes did not show any measurable effects,
B-cell-lymphoma-2 (Bcl-2) is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. It was the first apoptosis regulator identified in any organism1. Bcl-2 is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Orthologs (such as Bcl2 in mice) have been identified2 in numerous mammals for which complete genome data are available.
The compound LSL60101 improved cognitive deficit and biomarkers related to Alzheimer’s disease in studies carried out with mice. The work is described in a paper1 detailing the synthesis of a new family of compounds with high affinity and selectivity for imidazoline I2 receptors, altered in the brain of patients with Alzheimer’s. The synthesis pathway of compounds is efficient and affordable. It would allow different structural modifications to access a range of compounds of pharmaceutical interest.
Intelligence and good decision-making don’t always go together. Even the smartest people are capable of making some pretty foolish decisions. Decision-making is another one of those things that should be taught in schools. It would probably prove to be a more useful skill than precalculus in the typical day of most people. Credit: Unsplash/CC0 It only takes a few bad decisions to mess up your life if those decisions are critical enough.
The subventricular zone is a region situated on the outside wall of each lateral ventricle of the vertebrate brain. It is present in both the embryonic and adult brain. In embryonic life, the subventricular zone (SVZ) refers to a secondary proliferative zone containing neural progenitor cells, which divide to produce neurons in the process of neurogenesis. The primary neural stem cells of the brain and spinal cord, termed radial glial cells, instead reside in the ventricular zone (VZ) (so-called because the VZ lines the inside of the developing ventricles).
A novel biomarker indicating resilience to chronic stress has been found by researchers. This biomarker is largely absent in people suffering from major depressive disorder, and this absence is further associated with pessimism in daily life, their new study1 finds. To our knowledge, this is the first work to show that glutamate in the human medial prefrontal cortex shows an adaptive habituation to a new stressful experience if someone has recently experienced a lot of stress.
Neurofibromatosis type 1 (NF1), formerly called von Recklinghausen disease, is a common neurogenetic condition. Descriptions in art and literature of what is thought to be the condition go back as far back as 1500 BC. In 1882 the disease entity was fully recognized when the German pathologist Frederick von Recklinghausen published his monograph “On Multiple Fibromas of the Skin and Their Relationship to Multiple Neuromas”1, in which he described the disease as well as the origin of skin tumors.
By identifying a possible novel cellular mechanism for migraines, researchers may have also found a new way to treat chronic migraine. The goal of the research1 was to find a new mechanism of chronic migraine and propose a cellular pathway for migraine therapies. Senior author Amynah Pradhan is associate professor of psychiatry at the University of Illinois Chicago. He explained that the dynamic process of routing and rerouting connections among nerve cells, called neural plasticity, is critical to both the causes and cures for disorders of the central nervous system such as depression, chronic pain, and addiction.