BAF Complex Inhibition Induces Fast Loss Of DNA Accessibility

Silencing BAF complex function results in almost a total loss of chromatin accessibility at BAF-controlled sites, a new paper1 has found. When human cells need to acclimate to a various external influences, the BRG1/BRM-associated factor (BAF) complex is central to the process - it regulates the accessibility of the DNA and the information stored in it. In one out of five human cancers, a mutation is found in one of the BAF complex genes.

Low-dose ISRIB Restores Protein Synthesis And Cognition

A possible way to address loss of cognitive function due to Alzheimer’s disease by targeting protein synthesis has been identified by researchers. The findings1 show that synthetic pharmaceuticals could rescue the activity of brain cells needed for memory formation. This work is the first to show that reversing impaired protein synthesis in brains afflicted by Alzheimer’s disease through a pharmacological approach is not only feasible, but also effective, says lead author Mauricio Martins-Oliveira, a postdoctoral researcher at New York University’s Center for Neural Science.

Immune Hubs In The Meninges Enable Central Nervous System Immunosurveillance

Immune cells fill pockets in the outer layer of the meninges — the tissue that covers the brain and spinal cord — where they sample cerebrospinal fluid as it washes out of the brain, a new study finds. If the cells detect signs of infection, disease, or injury, they are prepared to initiate an immune response to confront the problem, the researchers say. The findings1 open up the possibility of targeting immune cells at such surveillance sites as a means of treating conditions driven by brain inflammation.

Amygdala Connectivity Changes After Exposure Therapy For PTSD

A new neuroimaging study investigates how psychotherapy for people with PTSD changes the brain areas responsible for generating emotional responses to threats used. Trauma-focused psychotherapy is considered the best available treatment for post-traumatic stress disorder (PTSD). However, the ways in which this method affects the brain to promote recovery from PTSD are not well understood. We know that psychotherapy works. But we don’t have a lot of good data to explain how it works, how the brain is changed by going through this process.

G3BPs At The Lysosomal Surface Inhibit mTORC1

The signaling protein mTOR (Mechanistic Target of Rapamycin) is a sensor for nutrients such as amino acids and sugars. When sufficient nutrients are available, mTOR boosts metabolism and ensures that sufficient energy and cellular building blocks are available. Since mTOR is a central switch for metabolism, errors in its activation lead to serious diseases. Cancers and developmental disorders of the nervous system leading to behavioral disorders and epilepsy can be the result if mTOR is malfunctioning.

Oleic Acid In Diet Could Help Against Multiple Sclerosis

Lack of a specific fatty acid in fat tissue can trigger the abnormal immune system response that causes multiple sclerosis (MS) by attacking and damaging the central nervous system, according to a new study1. Fat tissue in patients diagnosed with MS were found to have abnormal levels of oleic acid, a monounsaturated fatty acid found at high levels in cooking oils, meats (beef, chicken, and pork), cheese, nuts, sunflower seeds, eggs, pasta, milk, olives, and avocados.

Toxoplasma Infection Linked With Adult Glioma Risk

Individuals who have the brain cancer type glioma are more likely to have antibodies to T. gondii, indicating that they have had a previous infection, compared to a similar group that was cancer free, new research1 has found. The results suggest that reducing exposure to this common food-borne pathogen could provide a modifiable risk factor for highly aggressive brain tumors in adults. Led by James Hodge, JD, MPH and Anna Coghill, Ph.

Motor Intention Arm Training Targets Post-stroke Neuroplasticity

Survivors of stroke who no longer benefitted from conventional rehabilitation gained clinically significant arm movement and control by using an external robotic device powered by the patients' own brains, a new study1 found. The work showed most patients kept the benefits for at least two months after the therapy sessions ended, suggesting the potential for long-lasting gains, said Jose Luis Contreras-Vidal, director of the Non-Invasive Brain Machine Interface Systems Laboratory at the University of Houston.