What Is Nilotinib?

Nilotinib (brand name Tasigna) is an oral medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome. It may be used both in initial cases of chronic phase CML as well as in accelerated and chronic phase CML that has not responded to imatinib. Nilotinib is a Bcr-Abl tyrosine kinase inhibitor and…

Nerve-blocking Antibody Relieves Chronic Low Back Pain

Tanezumab, a monoclonal antibody that inhibits nerve activity, may provide relief to people with chronic low back pain, new research indicates. Chronic low back pain is one of the leading reasons why people seek medical care and the number one cause of disability worldwide. “This demonstration of efficacy is a major breakthrough in the global…

Dasatinib

Dasatinib (brand name Sprycel) is a a tyrosine-kinase inhibitor medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Specifically it is used to treat cases that are Philadelphia chromosome-positive (Ph+). Dasatinib was approved for medical use in the United States and in the European Union in 2006. The…

Are We All OCD Now, With Obsessive Hand-Washing And Technology Addiction?

One of the hallmarks of obsessive-compulsive disorder is contamination fears and excessive hand-washing. Years ago, a patient with severe OCD came to my office wearing gloves and a mask and refused to sit on any of the “contaminated” chairs. Now, these same behaviors are accepted and even encouraged to keep everyone healthy. This new normal…

The Places You Go (Or Don't) Can Change Your Personality

The places where we spend time seem to influence our personalities, new research reports[1]. The findings suggest that the places we choose to frequent can affect not only our thinking, feelings, or behavior in the moment, but may actually change our personalities over time. If complying with shelter-in-place orders has made you feel more disorganized…

Brain Organoids With The Potential To Predict Drug Permeability

The human brain is bathed in a supportive fluid called the cerebrospinal fluid (CSF) that provides nutrients and is required for proper brain function. The composition of human CSF and how it is made are poorly understood due to a lack of experimental access. Madeline Lancaster’s group in the Medical Research Council of England’s Laboratory…

Memory: How The Brain Constructs Dreams

Our most vivid dreams are a remarkable replication of reality, combining disparate objects, actions and perceptions into a richly detailed hallucinatory experience. How does our brain accomplish this? It has long been suspected that the hippocampus contributes to dreaming, in part due to its close association with memory: according to one estimate, about half of…

Researchers Discover The Mathematical System Used By The Brain To Organize Visual Objects

The brain uses a mathematical system to organize visual objects according to their principal components, researchers at Caltech have found. The work shows that the brain contains a two-dimensional map of cells representing different objects. The location of each cell in this map is determined by the principal components (or features) of its preferred objects;…