Oxytocin May Predict Postpartum Depression Risk


For pregnant women who have previously suffered from depression, higher levels of oxytocin in the third trimester may predict the severity of postpartum depression symptoms.

Says lead investigator Suena Massey, assistant professor of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine:

“It’s not ready to become a new blood test yet. But it tells us that we are on the track to identifying biomarkers to help predict postpartum depression.”

The link between depressive symptoms and higher level of oxytocin was a surprise. Researchers expected it to be associated with lower oxytocin.

“There’s emerging research that a past history of depression can change the oxytocin receptor in such a way that it becomes less efficient,” Massey says. “Perhaps, when women are starting to experience early signs of depression, their bodies release more oxytocin to combat it.”

For the small study published in Archives of Women’s Mental Health, scientists recruited 66 pregnant healthy women who were not depressed. They measured oxytocin levels in the third trimester and depression symptoms six weeks postpartum.

Earlier Preventive Treatment

Of that group, 13 of the women had a prior history of depression before the pregnancy. Among these women, the higher their oxytocin levels, the more depressive symptoms they experienced at six weeks.

Symptoms included waking up too early in the morning and not being able to get back to sleep, more worrying or anxiety, more aches and pains, headaches, changes in bowel patterns, feeling tired or a sense of heaviness, changes in appetite, and feeling sad. Oxytocin is a hormone that has many functions in the body, including delivery and lactation, mother-child bonding, and stress management.

Many mothers with postpartum depression feel that they are failing, because they believe they should be happy, Massey says.

“This decreases the likelihood that they will seek or accept help. If we can identify the women during pregnancy who are destined to develop postpartum depression, we can begin preventive treatment.”

Obstetricians routinely screen for non-psychiatric complications of childbearing such as gestational diabetes, using readily available biomarkers. The same should be true for pregnancy-related depression, Massey says.

“In light of the far reaching consequences of untreated postpartum depression to women and their children, the ability to predict which individuals are at greatest risk for developing it yields the exciting possibility for prevention.”

  1. Suena H. Massey, et al. Interaction of oxytocin level and past depression may predict postpartum depressive symptom severity. Archives of Women’s Mental Health; doi: 10.1007/s00737-016-0616-6

Last Updated on November 11, 2023