“Over a billion people worldwide are affected by vitamin D deficiency, and there is a well-established link between vitamin D deficiency and impaired cognition. Unfortunately, exactly how vitamin D influences brain structure and function is not well understood, so it has remained unclear why deficiency causes problems,”
said Associate Professor Thomas Burne at UQ’s Queensland Brain Institute, who led the studies.
Dr Burne’s team found that vitamin D levels affect a type of ‘scaffolding’ in the brain, called perineuronal nets.
“These nets form a strong, supportive mesh around certain neurons, and in doing so they stabilise the contacts these cells make with other neurons,”
Researchers removed vitamin D from the diet of a group of healthy adult mice, and after 20 weeks found a significant decline in their ability to remember and learn compared to a control group.
The vitamin D deficient group had a pronounced reduction in perineuronal nets in the hippocampus, the brain region crucial to memory formation.
“There was also a stark reduction in both the number and strength of connections between neurons in that region,”
Dr Burne said.
Vitamin D Deficiency
Dr Burne’s team propose that vitamin D plays an important role in keeping perineuronal nets stable, and that when vitamin D levels drop, this ‘scaffolding’ is more easily degraded by enzymes.
“As neurons in the hippocampus lose their supportive perineuronal nets, they have trouble maintaining connections, and this ultimately leads to a loss of cognitive function. It’s like the canary in the coalmine — it might fail first because its high energy requirement makes it more sensitive to the depletion of essential nutrients like vitamin D. Intriguingly, the right side of the hippocampus was more affected by vitamin D deficiency than the left side.”
Burne said loss of function in this area could be an important contributor to the hallmarks of schizophrenia, including severe memory deficits and a distorted perception of reality.
“The next step is to test this new hypothesis on the link between vitamin D deficiency, perineuronal nets and cognition,”
Al-Amin, M.M., Sullivan, R.K.P., Kurniawan, N.D. et al.
Adult vitamin D deficiency disrupts hippocampal-dependent learning and structural brain connectivity in BALB/c mice
Brain Struct Funct (2019). https://doi.org/10.1007/s00429-019-01840-w
Phoebe E. Mayne et al.
Vitamin D in Synaptic Plasticity, Cognitive Function, and Neuropsychiatric Illness
Trends in Neurosciences (2019). DOI: 10.1016/j.tins.2019.01.003