A new subtype of multiple sclerosis, called myelocortical MS, has been discovered by researchers at Cleveland Clinic.
Multiple sclerosis (MS) has long been characterized as a disease of the brain’s white matter, where immune cells destroy myelin — the fatty protective covering on nerve cells. The destruction of myelin (called demyelination) was believed to be responsible for neuron death that leads to irreversible disability in patients with MS.
However, in the new findings, a research team led by Bruce Trapp, Ph.D., identified for the first time a subtype of the disease that features neuronal loss but no demyelination of the brain’s white matter. The findings could potentially lead to more personalized diagnosis and treatments.
Myelocortical MS (MCMS), was indistinguishable from traditional MS on MRI. The researchers observed that in MCMS, part of the neurons become swollen and look like typical MS lesions indicative of white matter myelin loss on MRI.
The disease was only diagnosed in post-mortem tissues.
The team’s findings support the concept that neurodegeneration and demyelination can occur independently in MS and underscore the need for more sensitive MRI imaging techniques for evaluating brain pathology in real time and monitoring treatment response in patients with the disease.
“This study opens up a new arena in MS research. It is the first to provide pathological evidence that neuronal degeneration can occur without white matter myelin loss in the brains of patients with the disease. This information highlights the need for combination therapies to stop disability progression in MS,"
said Trapp, chair of Cleveland Clinic’s Lerner Research Institute Department of Neurosciences.
White Matter Lesions
In the study of brain tissue from 100 MS patients who donated their brains after death, the researchers observed that 12 brains did not have white matter demyelination. They compared microscopic tissue characteristics from the brains and spinal cords of 12 MCMS patients, 12 traditional MS patients and also individuals without neurological disease.
Although both MCMS and traditional MS patients had typical MS lesions in the spinal cord and cerebral cortex, only the latter group had MS lesions in the brain white matter.
Despite having no typical MS lesions in the white matter, MCMS brains did have reduced neuronal density and cortical thickness, which are hallmarks of brain degeneration also observed in traditional MS. Contrary to previous belief, these observations show that neuronal loss can occur independently of white matter demyelination.
“The importance of this research is two-fold. The identification of this new MS subtype highlights the need to develop more sensitive strategies for properly diagnosing and understanding the pathology of MCMS. We are hopeful these findings will lead to new tailored treatment strategies for patients living with different forms of MS,"
said Daniel Ontaneda, M.D., clinical director of the brain donation program at Cleveland Clinic’s Mellen Center for Treatment and Research in MS.
Prof Bruce D Trapp Megan Vignos, Jessica Dudman, Ansi Chang, Elizabeth Fisher, Susan M Staugaitis, PhDHarsha Battapady, Prof Sverre Mork, Daniel Ontaneda, Prof Stephen E Jones, Prof Robert J Fox, Jacqueline Chen, Kunio Nakamura, Prof Richard A Rudick Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: a retrospective study Lancet Neurology DOI:https://doi.org/10.1016/S1474-4422(18)30245-X
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