With the use of MRI scans, it is possible to distinguish between memory loss caused by Alzheimer’s disease and traumatic brain injury, according to a UCLA-led study. The finding[1] is important because it could help prevent a misdiagnosis of Alzheimer’s disease, which can be devastating for patients and their families.

A previous study found that as many as 21 percent of older adults with dementia may be misdiagnosed with Alzheimer’s disease[2]. A misdiagnosis can result in patients not receiving the appropriate treatment, and prevents them from participating in clinical trials that could improve their overall care.

“We already knew that MRIs can reveal subtle abnormalities in patients with neurological disorders, such as Alzheimer’s. The purpose of our study was to evaluate whether MRI also could reveal distinct abnormalities in traumatic brain injury. And, if we could identify such a pattern, it would lead to improved diagnosis of TBI-related memory loss from other causes of dementia,"

said Dr. Somayeh Meysami, lead author and a postdoctoral clinical research fellow in cognitive and behavioral neurology at the David Geffen School of Medicine at UCLA.

The Ventral Diencephalon

The current study involved 40 UCLA patients with an average age of just under 68, who had suffered traumatic brain injury, or TBI, and later developed memory problems.

According to the U.S. Centers for Disease Control and Prevention 2.87 million Americans experienced TBI in 2014, with the rates highest for people age 75 or older. Children age 4 and younger, and adults age 65 and older were most likely to suffer serious brain injuries after a fall.

Using a software program to analyze the MRI scans, the study revealed that TBI caused the most damage to a brain region known as the ventral diencephalon, with the least amount of atrophy occurring in the hippocampus, said study author Dr. Cyrus Raji, an assistant professor of radiology at Washington University in St. Louis. The ventral diencephalon is associated with learning and emotions, whereas the hippocampus is involved in memory and emotions.

The hippocampus also is the region of the brain that is most impacted by Alzheimer’s disease.

The Alzheimer’s Association estimates that up to 40 percent of dementias are caused by conditions other than Alzheimer’s disease.

[1] Somayeh Meysami, Cyrus A. Raji, David A. Merrill, Verna R. Porter, Mario F. Mendez. MRI Volumetric Quantification in Persons with a History of Traumatic Brain Injury and Cognitive Impairment. Journal of Alzheimer’s Disease, 2019 DOI: 10.3233/JAD-190708

[2] Thomas R Skinner, Ian A Scott, and Jennifer H Martin. Diagnostic errors in older patients: a systematic review of incidence and potential causes in seven prevalent diseases. Int J Gen Med. 2016; 9: 137–146.


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