A link between milk consumption and the levels of a naturally-occurring antioxidant called glutathione in the brain in older, healthy adults has been found by researchers at the University of Kansas Medical Center.

The research suggests a new way that drinking milk could benefit the body. Debra Sullivan, Ph.D., professor and chair of dietetics and nutrition at KU Medical Center said:

“We have long thought of milk as being very important for your bones and very important for your muscles. This study suggests that it could be important for your brain as well."

In-Young Choi, Ph.D., an associate professor of neurology at KU Medical Center, worked with Sullivan on the project.

Choi’s team asked the 60 participants in the study about their diets in the days leading up to brain scans, which they used to monitor levels of glutathione in the brain.

Glutathione and Oxidative Stress

The researchers found that participants who had indicated they had drunk milk recently had higher levels of glutathione in their brains.

This is important, the researchers said, because glutathione could help stave off oxidative stress and the resulting damage caused by reactive chemical compounds produced during the normal metabolic process in the brain.

Oxidative stress is known to be associated with a number of different diseases and conditions, including Alzheimer’s disease, Parkinson’s disease and many other conditions, said Dr. Choi.

“You can basically think of this damage like the buildup of rust on your car,” Sullivan said. “If left alone for a long time, the buildup increases and it can cause damaging effects."

Few Americans reach the recommended daily intake of three dairy servings per day, Sullivan said. The new study showed that the closer older adults came to those servings, the higher their levels of glutathione were.

Choi said:

“If we can find a way to fight this by instituting lifestyle changes including diet and exercise, it could have major implications for brain health.

Antioxidants are a built-in defense system for our body to fight against this damage, and the levels of antioxidants in our brain can be regulated by various factors such as diseases and lifestyle choices”

For the study, researchers used high-tech brain scanning equipment housed at KU Medical Center’s Hoglund Brain Imaging Center.

“Our equipment enables us to understand complex processes occurring that are related to health and disease,” Choi said. “The advanced magnetic resonance technology allowed us to be in a unique position to get the best pictures of what was going on in the brain."

A randomized, controlled trial that seeks to determine the precise effect of milk consumption on the brain is still needed and is a logical next step to this study, the researchers said.


In-Young Choi, Phil Lee, Douglas R Denney, Kendra Spaeth, Olivia Nast, Lauren Ptomey, Alexandra K Roth, Jo Ann Lierman, and Debra K Sullivan Dairy intake is associated with brain glutathione concentration in older adults Am J Clin Nutr 2015 101: 287-293; doi:10.3945/ajcn.114.096701

Photo: Guy Montag

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