Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons, research indicates[1].

The findings, from an international research team led by the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, are based on the analyses of human brain tissue and further lab studies.

In the particular case of Alzheimer’s the results reveal a hitherto unknown connection between Amyloid beta and tau pathology. Furthermore, the results indicate that inflammatory processes represent a potential target for future therapies.

Tau Pathology

Tau proteins usually stabilize a neuron’s skeleton. However, in Alzheimer’s disease, frontotemporal dementia (FTD), and other “tauopathies,” these proteins are chemically altered, they detach from the cytoskeleton and stick together.

As a consequence, the cell’s mechanical stability is compromised to such an extent that it dies off. In essence, “tau pathology” gives neurons the deathblow.

The current study led by Prof. Michael Heneka, director of the Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn and a senior researcher at the DZNE, provides new insights into why tau proteins are transformed.

As it turns out, inflammatory processes triggered by the brain’s immune system are a driving force.

NLRP3 Inflammasome

A particular protein complex, the NLRP3 inflammasome, plays a central role for these processes, the researchers report. Heneka and colleagues studied this macromolecule, which is located inside the brain’s immune cells, in previous studies.

It is a molecular switch that can trigger the release of inflammatory substances. For the current study, the researchers examined tissue samples from the brains of deceased FTD patients, cultured brain cells, and mice that exhibited hallmarks of Alzheimer’s and FTD.

“Our results indicate that the inflammasome and the inflammatory reactions it triggers, play an important role in the emergence of tau pathology. It appears that inflammatory processes mediated by the inflammasome are of central importance for most, if not all, neurodegenerative diseases with tau pathology,"

Heneka said. In particular, the researchers discovered that the inflammasome influences enzymes that induce a hyperphosphorylation of tau proteins. This chemical change ultimately causes them to separate from the scaffold of neurons and clump together.

Amyloid Cascade Hypothesis

This especially applies to Alzheimer’s disease. Here another molecule comes into play: amyloid beta (Abeta).

In Alzheimer’s, this protein also accumulates in the brain. In contrast to tau proteins, this does not happen within the neurons but between them. In addition, deposition of Abeta starts in early phases of the disease, while aggregation of tau proteins occurs later.

In previous studies, Heneka and colleagues were able to show that the inflammasome can promote the aggregation of Abeta. Here is where the connection to the recent findings comes in.

“Our results support the amyloid cascade hypothesis for the development of Alzheimer’s. According to this hypothesis, deposits of Abeta ultimately lead to the development of tau pathology and thus to cell death,” said Heneka. “Our current study shows that the inflammasome is the decisive and hitherto missing link in this chain of events, because it bridges the development from Abeta pathology to tau pathology. It passes the baton, so to speak."

Thus, deposits of Abeta activate the inflammasome. As a result, formation of further deposits of Abeta is promoted.

On the other hand, chemical changes occur to the tau proteins resulting into their aggregation.

“Inflammatory processes promote the development of Abeta pathology, and as we have now been able to show, of tau pathology as well. Thus, the inflammasome plays a key role in Alzheimer’s and other brain diseases. The idea of influencing tau pathology is obvious. Future drugs could tackle exactly this aspect by modulating the immune response. With the development of tau pathology, mental abilities decline more and more. Therefore, if tau pathology could be contained, this would be an important step towards a better therapy,"

said Heneka.

[1] Christina Ising, Carmen Venegas, Shuangshuang Zhang, Hannah Scheiblich, Susanne V. Schmidt, Ana Vieira-Saecker, Stephanie Schwartz, Shadi Albasset, Róisín M. McManus, Dario Tejera, Angelika Griep, Francesco Santarelli, Frederic Brosseron, Sabine Opitz, James Stunden, Maximilian Merten, Rakez Kayed, Douglas T. Golenbock, David Blum, Eicke Latz, Luc Buée & Michael T. Heneka. NLRP3 inflammasome activation drives tau pathology. Nature (2019) doi:10.1038/s41586-019-1769-z

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