Imipramine and Bed Wetting

Imipramine, which is sold under the names Tofranil, Antideprin and Janimine, is a tricyclic antidepressant that is used to treat both nocturnal enuresis as well as clinical depression. This drug, under the name Tofranil, was the very first medication that was ever used to treat the problem of wetting the bed at night.

This drug first appeared on the market in the late 1950s and was used for depression before it came to be used for enuresis. This drug is not used as much today as it was in past years but is sometimes used as a back up for depression when other treatments fail to bring about the desired results.

In limited quantities it has also been used to treat migraine headaches, post concussive syndrome and attention deficit disorder (ADD). As well in hospitals it is sometimes given to patients who suffer chronic pain or who are in the middle of a panic attack.

Tofranil Use

The purpose of this drug in regards to bed wetting is that it supports a child in having a restful and peaceful sleep during the night. It also helps to encourage the strength and smoothness of the bladder muscles in retaining urine throughout the night.

Research studies have borne out the result that only approximately thirty percent of children who are prescribed this medication are actually helped by it.

Relapse is very common once the drug is stopped. This medication can be dangerous for children under six years of age and is therefore only prescribed for those who are older than six.

Side Effects

Imipramine is available in both capsule and tablet form but can cause a number of side effects and therefore needs to be closely monitored by a patients doctor. Some of the side effects it is known to cause include dry mouth, tremors, constipation, insomnia, drowsiness, excessive perspiration, a flushed complexion, weight gain, anxiety, irritability, moodiness and loss of appetite.

Sometimes this drug is prescribed for elderly people with bed wetting problems and they can suffer serious side effects as well. In the elderly the most common side effects which should be closely monitored by a health expert include confusion, delirium, agitation, and irritability.


In child patients this drug is usually started with a dose of ten milligrams daily and from there it is adjusted according to how the patient is reacting to it. If there are side effects noted then the dose with be altered and/or the drug will be discontinued all together. The weight of a patient is also taken into account at the time the drug is first administered.

In regards to bed wetting, Imipramine is safe in most cases but as previously mentioned due to its potential side effects, must be closely monitored by a doctor. If doctor supervision on a regular basis is not available, this drug should be passed over for another treatment option.

This drug is reasonably priced and should be covered by most health plans. It is always a good idea to check with your insurance company before committing to any medical drug treatment. Your doctor should be able to answer any and all questions you have regarding this form of medication.