Cells in the nervous system can dampen the immune response to infections in the gut and lungs to prevent excessive inflammation, indicates research by scientists at Weill Cornell Medicine. The finding could eventually lead to new ways to treat diseases caused by unchecked inflammation, such as asthma and inflammatory bowel disease.

The work provides some clues about what might be going wrong in these diseases, which have become more common in industrialized countries, and in helminth infections, which are still a major public health problem in less-industrialized countries. It also may explain how some existing treatments for diseases like asthma work and point to new treatment strategies.

“There is a crosstalk between the nervous system and the immune system, and that plays an important role in regulating acute and chronic inflammation. Those two organ systems are closely interacting and play an important role in human health and disease,"

said Dr. David Artis, director of the Jill Roberts Institute for Research in Inflammatory Bowel Disease and the Michael Kors Professor of Immunology at Weill Cornell Medicine.

Group 2 Innate Lymphoid Cells

Dr. Artis and his colleagues investigated communication between the nervous system and immune system during the kind of inflammatory response that is triggered by allergens or infections with parasites called helminths.

Exposure to these agents causes a class of immune cells called group 2 innate lymphoid cells (ILC2) to release inflammatory molecules called cytokines that can promote increased mucus production and muscle contractions - all of which help to expel the parasite or allergen from the body.

[caption id=“attachment_94603” align=“aligncenter” width=“680”]inflammatory Mucus production Mucus production (red) in the lung under inflammatory conditions.
Credit: Dr. Saya Moriyama[/caption]

Too much or prolonged inflammation can be harmful, so Dr. Artis and his team wanted to understand how the body dampens this response.

ILC2s have receptors on their surface called β2 adrenergic receptors (β2AR) that interact with a chemical called norepinephrine that nerve cells release. These receptors give nerve cells the ability to interact with each other and influence the immune response.

Blunted Immune Response

To determine the role of β2AR in communication between the two systems, Dr. Artis and his colleagues employed mice that lack the receptor and then infected them with helminths. The rodents had an exaggerated immune response to the infection and faster expulsion of the parasites.

By contrast, when they treated normal mice with drugs that stimulate β2AR, the immune response was blunted and the helminth infections worsened.

“We found that those beta-adrenergic receptors controlled the proliferation of the ILC2 cells,"

said lead author Dr. Saya Moriyama, a postdoctoral associate in Dr. Artis' laboratory, noting that the receptors may help prevent too much inflammation.

If these results are confirmed in humans, it could have very important implications for patients with asthma, allergies and other types of inflammatory diseases.

The most commonly used drugs to treat asthma also stimulate β2AR, which may explain why they are so effective at controlling allergy symptoms.

“We must have given tens of millions of doses of these drugs to shut down the acute symptoms of asthma. Nobody could agree on how these drugs work, but it may be that they are working in part through targeting the innate immune system."

Dr. Artis said.

Saya Moriyama, Jonathan R. Brestoff, Anne-Laure Flamar, Jesper B. Moeller, Christoph S. N. Klose, Lucille C. Rankin, Naomi A. Yudanin, Laurel A. Monticelli, Gregory Garbès Putzel, Hans-Reimer Rodewald, David Artis β2-adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responses Science 02 Mar 2018: Vol. 359, Issue 6379, pp. 1056-1061 DOI: 10.1126/science.aan4829

Top Image: mouse intestine showing ILC2-dependent mucus production (purple) Credit: Dr. Saya Moriyama

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