Scientists have identified peptides from parasitic hookworms that can calm the body’s immune response and perhaps pave the way to treat autoimmune diseases.
Autoimmune diseases occur when a person’s immune system has an abnormal response against its own cells, tissues, or even entire organs, resulting in inflammation and damage.
Lead researcher Professor Ray Norton from Monash Institute of Pharmaceutical Sciences (MIPS) says experts around the world have yet to fully understand the causes of autoimmune diseases, which have risen significantly in parts of the world.
Rise in Autoimmune Disease
“There are more than eighty autoimmune diseases, ranging in severity from mild to life threatening in some cases. While some affect mainly one area or organ, others can affect many parts of the body,” he says.
“Many people believe there’s a link between the rise in autoimmune diseases and an increased focus on cleanliness in western societies, because the immune system is no longer exposed to the broad range of infections that previous generations had to deal with.
There could be some truth to this because worm infection is virtually unheard of in developed countries, yet the incidence of autoimmune diseases is high. But in developing countries the opposite is true,” Norton says
The new line of research offers an alternative to helminthic therapy, where people deliberately infect themselves with parasitic worms, in an attempt to put their autoimmune disease into remission. It’s thought that the worms have a calming effect on their host’s immune systems in order to ensure their survival.
Potassium Channel Inhibitor
Rather than using worms, the research team searched for the active components responsible for immunomodulatory effects in parasitic worms. By creating a cDNA library from the anterior secretory glands of the parasitic hookworm Ancylostoma caninium, they identified a peptide called AcK1 that dampens the immune system by inhibiting a potassium channel.
Researchers found that AcK1 closely resembles ShK, a peptide from a sea anemone that has been shown to suppress autoimmune diseases and is currently in clinical trials for the treatment of multiple sclerosis.
Sandeep Chhabra from MIPS says the study will help in developing new drugs to treat autoimmune diseases.
“Our research shows that it is possible to identify individual molecules responsible for this beneficial affect,” he says.
“The next step will be to see if we can develop this into a pill that could dampen the immune system in people with an autoimmune disease. That’s a whole lot cleaner than putting a worm in your body,” Chhabra says.
Sandeep Chhabra, et al. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases FASEB Journal; doi: 10.1096/fj.14-251967 fj.14-251967
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