Diets high in fat have long been known to increase the risk for medical problems, including heart disease and stroke, but could the consumption of fatty foods change your behavior and your brain?
There is growing concern that these diets might also increase the risk for depression and other psychiatric disorders.
A new study from researchers at Louisiana State University raises the possibility that a high-fat diet produces changes in health and behavior, in part, by changing the mix of bacteria in the gut, also known as the gut microbiome.
The Microbiome and Neuropsychiatric Impairment
The human microbiome consists of trillions of microorganisms, many of which reside in the intestinal tract.
These microbiota are essential for normal physiological functioning. However, research has suggested that alterations in the microbiome may underlie the host’s susceptibility to illness, including neuropsychiatric impairment.
This led the researchers to test whether an obesity-related microbiome alters behavior and cognition even in the absence of obesity.
Non-obese adult mice were conventionally housed and maintained on a normal diet, but received a transplant of gut microbiota from donor mice that had been fed either a high-fat diet or control diet. The recipient mice were then evaluated for changes in behavior and cognition.
The animals who received the microbiota shaped by a high-fat diet showed multiple disruptions in behavior, including increased anxiety, impaired memory, and repetitive behaviors.
Detrimental Side Effects
Not only that, but they exhibited many detrimental effects in the body, including increased intestinal permeability and markers of inflammation. Signs of inflammation in the brain were also evident and may have contributed to the behavioral changes.
Dr. John Krystal, Editor of Biological Psychiatry said:
“This paper suggests that high-fat diets impair brain health, in part, by disrupting the symbiotic relationship between humans and the microorganisms that occupy our gastrointestinal tracks."
These findings provide evidence that diet-induced changes to the gut microbiome are sufficient to alter brain function even in the absence of obesity.
This is consistent with prior research, which has established an association between numerous psychiatric conditions and gastrointestinal symptoms, but unfortunately, the mechanisms by which gut microbiota affect behavior are still not well understood.
Further research is necessary, but these findings suggest that the gut microbiome has the eventual potential to serve as a therapeutic target for neuropsychiatric disorders.
Annadora J. Bruce-Keller, J. Michael Salbaum, Meng Luo, Eugene Blanchard, Christopher M. Taylor, David A. Welsh, Hans-Rudolf Berthoud. Obese-type Gut Microbiota Induce Neurobehavioral Changes in the Absence of Obesity. Biological Psychiatry, 2015; 77 (7): 607 DOI: 10.1016/j.biopsych.2014.07.012