Head Injury, Not Concussion, May Cause CTE


Chronic traumatic encephalopathy (CTE) results from head injuries, not concussions, new research suggests.

The research explains why 20 percent of athletes who exhibited the early stages of the progressive brain illness postmortem never had a diagnosed concussion.

“It’s the hits to the head, not concussion, that trigger CTE,”

says study coauthor Lee Goldstein, an associate professor of psychiatry at Boston University’s School of Medicine, who also has an appointment at the College of Engineering. The study suggests that head injuries can cause blood vessels to leak proteins into adjacent brain tissues, inflaming them.

Chronic Traumatic Encephalopathy

Chronic traumatic encephalopathy is a brain disease characterized by accumulation of tau protein around the brain’s blood vessels. Researchers have found CTE in athletes, soldiers, and others who have suffered repeated concussions and other brain trauma.

CTE is associated with dementia, mood changes, and aggression. Concussions are injuries that impair a person’s functions, such as memory or balance.

The study’s finding is important because efforts to protect athletes focus on preventing concussions rather than repeated hits to the head, says Christopher Nowinski, codirector of BU’s Chronic Traumatic Encephalopathy Center.

In order to reduce CTE risk in athletes and military veterans,

“there must be a reduction in the number of head impacts. The continued focus on concussion and symptomatic recovery does not address the fundamental danger these activities pose to human health.”

says study coauthor Ann McKee, director of the CTE Center.

Damaged Brain Blood Vessels

McKee and her team first examined the brains of four dead teenage athletes who’d suffered head injuries 1, 2, 10, and 128 days before they died. They found a range of post-trauma pathologies, including one case of early CTE (the disease has four stages) and two brains with abnormal tau accumulations.

When researchers compared the brains to those of four teenage athletes who had not suffered recent head trauma, they found that those brains did not have the same pathologies.

The researchers speculated that early CTE could result from damaged brain blood vessels that leak blood proteins into nearby tissue, causing inflammation of the brain. They tested the hypothesis by exposing lab mice to two different triggers linked to CTE: repeated head impacts and blast exposures.

They then scanned the mice brains and found leaky blood vessels, as well as persistent changes in electrical functions, possibly explaining cognitive impairment in some people after similar injuries.

“The same brain pathology that we observed in teenagers after head injury was also present in head-injured mice,” says Goldstein. “We were surprised that the brain pathology was unrelated to signs of concussion.”

The findings, he adds, provide strong causal evidence linking head impacts to both traumatic brain injury and early CTE, independent of concussion.


The researchers focused especially on capillaries, the smallest and most important blood vessels in the brain, Goldstein says, through which oxygen, nutrients, and waste removal occur.

Head impact results in focal disruption of capillaries, resulting in proteins leaking into the brain, he says.

The researchers also used computer simulations from Lawrence Livermore National Laboratory and mechanical models from BU, both of which showed that triggers for concussion and CTE may be distinct.

The National Institutes of Health, the Department of Veterans Affairs, the US Department of Defense, the US Department of Energy, and the National Football League provided funding for the study, among others.

Chad A Tagge, Andrew M Fisher, Olga V Minaeva, Amanda Gaudreau-Balderrama, Juliet A Moncaster, Xiao-Lei Zhang, Mark W Wojnarowicz, Noel Casey, Haiyan Lu, Olga N Kokiko-Cochran, Sudad Saman, Maria Ericsson, Kristen D Onos, Ronel Veksler, Vladimir V Senatorov, Asami Kondo, Xiao Z Zhou, Omid Miry, Linnea R Vose, Katisha R Gopaul, Chirag Upreti, Christopher J Nowinski, Robert C Cantu, Victor E Alvarez, Audrey M Hildebrandt, Erich S Franz, Janusz Konrad, James A Hamilton, Ning Hua, Yorghos Tripodis, Andrew T Anderson, Gareth R Howell, Daniela Kaufer, Garth F Hall, Kun P Lu, Richard M Ransohoff, Robin O Cleveland, Neil W Kowall, Thor D Stein, Bruce T Lamb, Bertrand R Huber, William C Moss, Alon Friedman, Patric K Stanton, Ann C McKee, Lee E Goldstein
Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model
Brain, awx350, https://doi.org/10.1093/brain/awx350

Last Updated on November 7, 2022