Glucosinolates In Horseradish Have Cancer-fighting Properties

Although the humble horseradish may not be much to look at, a recent University of Illinois study shows that it contains compounds that could help detoxify and eliminate cancer-causing free-radicals in the body. Known as glucosinolates, the type and quantity vary depending on size and quality of the horseradish root.

“We knew horseradish had health benefits, but in this study, we were able to link it to the activation of certain detoxifying enzymes for the first time,” says U of I crop scientist Mosbah Kushad.

Kushad’s research team had previously identified and quantified the compounds responsible for the cancer-fighting compounds, known as glucosinolates, in horseradish, noting that horseradish contains approximately 10 times more glucosinolates than its superfood cousin, broccoli.

Best of all, just a teaspoon of the pungent condiment is enough to get the benefit.

U.S. Fancy vs. U.S. No. 1 Horseradish

In the study, Kushad and his team looked for the products of glucosinolate hydrolysis, which activate enzymes involved in detoxification of cancer-causing molecules.

They compared the quantity and activity of these products in 11 horseradish strains rated U.S. Fancy, U.S. No. 1, or U.S. No. 2. The USDA puts fresh-market horseradish in these categories based on diameter and length of the root.

“There was no information on whether the USDA grade of the horseradish root is associated with cancer preventive activity, so we wanted to test that,” Kushad explains.

The group found that the higher-grade U.S. Fancy accessions had significantly more glucosinolates than U.S. No. 1. Concentrations of various glucosinolate hydrolysis products differed according to USDA grade, with U.S. Fancy having greater allyl isothiocyanate (AITC) and U.S. No. 1 having greater 1-cyano 2,3-epithiopropane (CETP).

The two compounds differ, with CETP being a comparatively weaker cancer-fighter than AITC. Still, the detection of CETP in horseradish is noteworthy, according to Kushad.

“To our knowledge, this is the first detection and measurement of CETP from horseradish,” he says.

The team suggests that AITC is a good dietary anti-carcinogen, not only because it activates the enzyme responsible for detoxifying cancer-causing molecules, but also because a large proportion of it, 90 percent, is absorbed when ingested.

Kang-Mo Ku, Elizabeth H. Jeffery, John A. Juvik, Mosbah M. Kushad
Correlation of Quinone Reductase Activity and Allyl Isothiocyanate Formation Among Different Genotypes and Grades of Horseradish Roots
Journal of Agricultural and Food Chemistry, 2015; 63 (11): 2947 DOI: 10.1021/jf505591z

Photo: Ken Hawkins/Flickr


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