A nutrient found in garlic could offer your brain cells protection against aging and disease, according to a new study from researchers at the University of Missouri School of Medicine.

Said lead author Zezong Gu, associate professor of pathology and anatomical sciences:

“Garlic is one of the most widely consumed dietary supplements. Most people think of it as a ‘superfood,’ because garlic’s sulfur-containing compounds are known as an excellent source of antioxidant and anti-inflammatory protection.

Scientists are still discovering different ways garlic benefits the human body. Our research focused on a carbohydrate derivative of garlic known as FruArg and the role this nutrient plays in protective responses.”

Brain Cell Damage

Gu’s team looked at the nutrient’s ability to inhibit, and even possibly reverse, brain cell damage caused by environmental stress. Environmental stress could include the aging process, smoking, pollution, traumatic brain injury, or excessive alcohol consumption.

Said Gu:

“Microglia are immune cells in the brain and spinal cord that are the first and main line of defense in the central nervous system.

Unlike other mature brain cells that seldom regenerate themselves, microglial cells respond to inflammation and environmental stresses by multiplying. By massing themselves and migrating toward an injury site, they are able to respond to inflammation and protect other brain cells from destruction.”

However, increasing the number of microglial cells won’t provide age-defying protection for the brain, Gu cautions. In fact, it can do more harm than good:

“Although important to brain cell health, microglial cells also produce nitric oxide in reaction to their function as protectors.

If we simply increased the number of microglial cells, we also would increase the amount of nitric oxide in the brain. Excessive production of nitric oxide leads to brain cell damage and promotes neurodegenerative diseases such as cerebral ischemia, Parkinson’s disease, and Alzheimer’s disease."

Increased Antioxidants

On the other hand, the nutrient FruArg may also provide an answer to this reactive dilemma. By creating a cell model of neurological stress and monitoring microglial cell function, Gu’s team was able to study FruArg’s contribution to brain health.

“When stress was applied to the model, there was an expected increase in microglial cells and their byproduct, nitric oxide,” Gu says. “However, once we applied FruArg, the microglial cells adapted to the stress by reducing the amount of nitric oxide they produced.

Additionally, FruArg promoted the production of antioxidants, which offered protective and healing benefits to other brain cells. This helps us understand how garlic benefits the brain by making it more resilient to the stress and inflammation associated with neurological diseases and aging.”

In the future, Gu and his colleagues hope to study the effects of FruArg on other cells in the body associated with conditions such as heart disease, diabetes, and cancer.


Zhou H, Qu Z, Mossine VV, Nknolise DL, Li J, et al. (2014) Proteomic Analysis of the Effects of Aged Garlic Extract and Its FruArg Component on Lipopolysaccharide-Induced Neuroinflammatory Response in Microglial Cells. PLoS ONE 9(11): e113531. doi:10.1371/journal.pone.0113531

Kyo E, Uda N, Kasuga S, Itakura Y (2001) Immunomodulatory effects of aged garlic extract. J Nutr 131:1075S–1079S.

Photo: Dubravko Sorić

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