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Stronger Functional Connectivity Linked To Youthful Memory In Older Adults

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Communication among neurons in various networks of the brain is associated with “superagers”, older adults who, despite their advanced age, maintain youthful memory, new research indicates.

The work is the second in a series of three studies undertaken to unlock the secret of something researchers already knew: that some adults in their 80s and 90s function cognitively as well as or better than much younger people.

The first study[1] showed that when compared with typical older adults, the brains of superagers are larger in certain areas that are important for processes that contribute to memory, including learning, storing, and retrieving information. But brain regions are not isolated islands; they form networks that “talk” to one another to allow for complex behaviors.

Superager Brain Structure

The current study[2] looked at superagers, typical adults from 60 to 80 years old, and young adults 18 to 35. It used functional magnetic resonance imaging (fMRI) to examine the synchronization of brain waves in the default mode network and salience network of participants in a resting state.

“This communication between brain regions is disrupted during normal aging. Superagers show not just youthful brain structure, but youthful connectivity as well,”

said Alexandra Touroutoglou, Ph.D., an investigator in the MGH Department of Neurology and the Athinoula A. Martinos Center for Biomedical Imaging.

“These networks ebb and flow, or oscillate, whether you’re in a resting state or engaged in a task. Our prediction was that typical older adults would have less synchronization in these brain waves—less efficient networks—but that superagers would have networks as efficient as the young adults. And that’s what we found,”

added Bradford C. Dickerson, MD, director of MGH’s Frontotemporal Disorders Unit.

Successful Aging Biomarkers

The research team’s next study will analyze fMRI data from brains engaged in memory and other cognitive tasks. It is hoped that taken together, the studies will

“provide basics for future researchers to develop biomarkers of successful aging,”

said Touroutoglou, who is also an instructor in neurology at Harvard Medical School. He noted that one of the mysteries scientists hope to tease out is whether superagers start off with “bigger and better” brain structure and communication than other people or if they are somehow more resilient to the declines of normal aging.

Future research may then measure the effects of genetics as well as exercise, diet, social connectedness, and other lifestyle factors that have been shown to affect resilience in older adults.

[1] Felicia W. Sun, Michael R. Stepanovic, Joseph Andreano, Lisa Feldman Barrett, Alexandra Touroutoglou, Bradford C. Dickerson. Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks Contributes to Youthful Memory in Superaging. Journal of Neuroscience 14 September 2016, 36 (37) 9659-9668; DOI: 10.1523/JNEUROSCI.1492-16.2016

[2] Jiahe Zhang, Joseph M Andreano, Bradford C Dickerson, Alexandra Touroutoglou, Lisa Feldman Barrett, Stronger Functional Connectivity in the Default Mode and Salience Networks Is Associated With Youthful Memory in Superaging, Cerebral Cortex, , bhz071, https://doi.org/10.1093/cercor/bhz071