A recent study by University of North Carolina researchers, involving brain scans of 152 infants, found disruptions in functional connectivity within part of the amygdala prefrontal network, a pathway thought to play an important role in arousal regulation.

According to Wei Gao, PhD, assistant professor of radiology in the University of North Carolina School of Medicine and one of the two corresponding authors of the study:

“To our knowledge, this study is the first to show that maternal drug use during pregnancy alters the brain’s functional organization in newborns."

The study was published in the April 8, 2015 issue of the Journal of Neuroscience.

Suppression of Amygdala Responses

Said Karen M. Grewen, PhD, the study’s second corresponding author and associate professor of psychiatry, neurobiology and psychology:

“This study may inform new strategies aimed at early risk identification and intervention."

For the study, 152 infants were given resting-state functional magnetic resonance imaging (rsfMRI) scans. Of these, 45 had prenatal exposure to cocaine, 43 had prenatal exposure to drugs other than cocaine, and 64 had no known prenatal drug exposure.

Alterations in the brain’s functional organization were found in both groups that had prenatal drug exposure. The group with prenatal cocaine exposure had additional alterations that the other drug control group did not have.

A reduced inverse correlation between the amygdala and part of the prefrontal cortex was found to be specifically associated with prenatal cocaine exposure, which may indicate a potential failure, or risk for failure, in the suppression of amygdala responses from the higher-order prefrontal cortex.

The disruption of this functional circuit may potentially underlie the arousal dysregulation trait frequently observed for infants with prenatal cocaine exposure.

Overall, this study revealed that rsfMRI in infants may play a pivotal role in the search for objective biomarkers for the identification of risks and guidance of early intervention to improve later behavioral outcomes.


A. P. Salzwedel, K. M. Grewen, C. Vachet, G. Gerig, W. Lin, W. Gao. Prenatal Drug Exposure Affects Neonatal Brain Functional Connectivity. Journal of Neuroscience, 2015; 35 (14): 5860 DOI: 10.1523/JNEUROSCI.4333-14.2015

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