How Endocannabinoids Regulate Habit Making


Although some habits functions as cognitive shortcuts and conserve brain processing, an inability to switch from behaving habitually to acting in a deliberate way can underlie addiction and obsessive compulsive disorders.

An international team of researchers, working with a mouse model, has now shown what happens in the brain for habits to control behavior.

According to study leader Christina Gremel, assistant professor of psychology at the University of California San Diego, the study provides the strongest evidence to date that the brain’s circuits for habitual and goal-directed action compete for control in the orbitofrontal cortex, a decision-making area of the brain.

It also shows that neurochemicals called endocannabinoids allow for habit to take over, by acting as a sort of brake on the goal-directed circuit.

Endocannabinoids and the Orbitofrontal Cortex

Endocannabinoids are a class of chemicals produced naturally by humans and other animals.

Receptors for endocannabinoids are found throughout the body and brain, and the endocannabinoid system is implicated in a variety of physiological processes, including appetite, pain sensation, mood and memory. It is also the system that mediates the psychoactive effects of cannabis.

Previous work by Gremel and Rui Costa, of the Champalimaud Centre for the Unknown in Lisbon, had shown that the orbitofrontal cortex, or OFC, is an important brain area for relaying information on goal-directed action.

They found that by increasing the output of neurons in the OFC with optogenetics, they increased goal-directed actions. In contrast, when they decreased activity in the same area with a chemical approach, they disrupted goal-directed actions and the mice relied on habit instead.

“Habit takes over when the OFC is quieted,” Gremel said.

For the current study, because endocannabinoids are known to reduce the activity of neurons in general, the researchers hypothesized that endocannabinoids may be quieting or reducing activity in the OFC and, with it, the ability to shift to goal-directed action. They focused particularly on neurons projecting from the OFC into the dorsomedial striatum.

Goal-directed vs. Habitual Action

They trained mice to perform the same lever-pressing action for the same food reward but in two different environments that differentially bias the development of goal-directed versus habitual actions. Like humans who don’t suffer from neuropsychiatric disorders, healthy mice will readily shift between performing the same action using a goal-directed versus habitual action strategy.

To stick with the earlier example of getting home, we can switch the homing autopilot off and shift to goal-directed behavior when we need to get to a new or different location.

To test their hypothesis on the role played by endocannabinoids, the researchers then deleted a particular endocannabinoid receptor, called cannabinoid type 1, or CB1, in the OFC-to-striatum pathway. Mice missing these receptors did not form habits, showing the critical role played by the neurochemicals as well as that particular pathway.

“We need a balance between habitual and goal-directed actions. For everyday function, we need to be able to make routine actions quickly and efficiently, and habits serve this purpose,” Gremel said. “However, we also encounter changing circumstances, and need the capacity to ‘break habits’ and perform a goal-directed action based on updated information. When we can’t, there can be devastating consequences."

The findings may suggest, the authors say, a new therapeutic target for people suffering from OCD or addictions. To stop overreliance on habit and restore the ability to shift from habit to goal-directed action, it may be helpful to treat the brain’s endocannabinoid system and so reduce habitual control over behavior.

Christina M. Gremel et al.
Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation
Neuron, May 2016 DOI: 10.1016/j.neuron.2016.04.043