Salmonella food poisoning can make you miserable for several days. New research suggests that some of its serotypes – variations of the bacterial species – can have permanent repercussions. It may damage your DNA, research by Cornell food scientists indicates.
Not all salmonella serotypes are equal, says study author Rachel Miller, a doctoral candidate in food science.
Salmonella is to blame for about 1.2 million non-typhoidal salmonella illnesses and about 450 deaths annually in the United States, according to Center for Disease Control statistics. There are over 2,500 serotypes for salmonella, but fewer than 100 serotypes cause the vast majority of foodborne illness, according to the CDC.
Cytolethal Distending Toxin
Miller and Martin Wiedmann, the Gellert Family Professor in Food Safety, examined multiple serotypes of salmonella that encode for cytolethal distending toxin, or S-CDT, a virulence component for serotype Typhi – the cause of typhoid fever. As it happens, the salmonella serotypes called Javiana, Montevideo, Oranienburg and Mississippi – common culprits in the foodborne illness world – also carry the genetic material that encodes S-CDT, the researchers found.
In human cells grown in the lab, Salmonella strains with S-CDT were also found to lead to hallmark signatures that indicate the presence of DNA damage. The ability to cause DNA damage may contribute to long-term disease consequences, Miller said.
“Think about possible DNA damage this way: We apply sunscreen to keep the sun from damaging our skin. If you don’t apply sunscreen, you can get a sunburn – and possibly develop skin problems later in life,” said Miller. “While not the sun, salmonella bacteria may work in a similar way. The more you expose your body’s cells to DNA damage, the more DNA damage that needs to be repaired, and there may one day be a chance that the DNA damage is not correctly repaired. We don’t really know right now the true permanent damage from these salmonella infections.”
For a half-century, scientists have used salmonella serotyping to track foodborne illness outbreaks and their sources.
“A person’s damaged DNA from salmonella could lead to long-term health consequences after the infection subsides, such as longer bouts with foodborne illness,” said Wiedmann.
Image: David Goulding, Wellcome Trust Sanger Institute, Wellcome Images
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