Depression Linked To Accelerated Cognitive Aging


Depression is associated with an acceleration of the rate at which the brain ages, research by psychologists at the University of Sussex suggests. It has previously been reported that people with depression or anxiety have an increased risk of dementia in later life, but this is the first study that provides comprehensive evidence for the effect of depression on the decline in overall cognitive function (also referred to as cognitive state), in a general population.

The researchers conducted a robust systematic review and meta-analysis of 34 longitudinal studies, with the focus on the link between depression or anxiety and decline in cognitive function over time. Evidence from more than 71,000 participants was combined and reviewed.

Including people who presented with symptoms of depression as well as those that were diagnosed as clinically depressed, the study looked at the rate of decline of overall cognitive state — encompassing memory loss, executive function (such as decision making) and information processing speed — in older adults.

Importantly, any studies of participants who were diagnosed with dementia at the start of study were excluded from the analysis. This was done in order to assess more broadly the impact of depression on cognitive ageing in the general population.

Greater Decline In Cognitive State

The study found that people with depression experienced a greater decline in cognitive state in older adulthood than those without depression. As there is a long pre-clinical period of several decades before dementia may be diagnosed, the findings are important for early interventions as currently there is no cure for the disease.

The lead authors of the paper, Dr. Darya Gaysina and Amber John from the EDGE (Environment, Development, Genetics and Epigenetics in Psychology and Psychiatry) Lab at the University of Sussex, are calling for greater awareness of the importance of supporting mental health to protect brain health in later life.

“This study is of great importance—our populations are ageing at a rapid rate and the number of people living with decreasing cognitive abilities and dementia is expected to grow substantially over the next thirty years. Our findings should give the government even more reason to take mental health issues seriously and to ensure that health provisions are properly resourced. We need to protect the mental wellbeing of our older adults and to provide robust support services to those experiencing depression and anxiety in order to safeguard brain function in later life,”

Dr. Gaysina, a Lecturer in Psychology and EDGE Lab Lead, said.

“Depression is a common mental health problem—each year, at least 1 in 5 people in the UK experience symptoms. But people living with depression shouldn’t despair—it’s not inevitable that you will see a greater decline in cognitive abilities and taking preventative measures such as exercising, practicing mindfulness and undertaking recommended therapeutic treatments, such as Cognitive Behaviour Therapy, have all been shown to be helpful in supporting wellbeing, which in turn may help to protect cognitive health in older age,”

researcher Amber John, who carried out this research for her Ph.D. at the University of Sussex added.

The work was supported by the Economic and Social Research Council (ESRC).

  1. John, A., Patel, U., Rusted, J., Richards, M., & Gaysina, D.
    Affective problems and decline in cognitive state in older adults: A systematic review and meta-analysis
    Psychological Medicine, 1-13. doi:10.1017/S0033291718001137

Last Updated on September 30, 2023