Child abuse and other traumatic childhood experiences may alter the brain, making the effects of trauma last into adulthood, a new study reveals.
The long-lasting effects may be due to an impaired structure and functioning of cells in the anterior cingulate cortex. This is a part of the brain which plays an important role in the regulation of emotions and mood.
The researchers believe that these changes may contribute to the emergence of depressive disorders and suicidal behavior.
Difficulties associated with severe childhood abuse include increased risks of psychiatric disorders such as depression, as well as high levels of impulsivity, aggressivity, anxiety, more frequent substance abuse, and suicide. Severe, non-random physical and/or sexual child abuse affects between 5-15 percent of all children under the age of 15 in the Western world.
White Matter Abnormalities
For the optimal function and organization of the brain, electrical signals used by neurons may need to travel over long distances to communicate with cells in other regions. A fatty coating called myelin covers the longer axons of this kind.
Myelin sheaths protect the axons and help them to conduct electrical signals more efficiently. Myelin builds up progressively (in a process known as myelination) mainly during childhood, and then continue to mature until early adulthood.
Earlier studies had shown significant abnormalities in the white matter in the brains of people who had experienced child abuse. White matter is mostly made up of thousands of myelinated nerve fibers stacked together.
But, because these observations were made by looking at the brains of living people using MRI, it was impossible to gain a clear picture of the white matter cells and molecules that were affected.
To gain a clearer picture of the microscopic changes which occur in the brains of adults who have experienced child abuse, the researchers compared post-mortem brain samples from three different groups of adults:
people who had committed suicide who suffered from depression and had a history of severe childhood abuse (27 individuals)
people with depression who had committed suicide but who had no history of being abused as children (25 individuals)
a third group of people who had neither psychiatric illnesses nor a history of child abuse (26 people)
The researchers discovered that the thickness of the myelin coating of a significant proportion of the nerve fibers was reduced only in the brains of those who had suffered from child abuse. They also found underlying molecular alterations that selectively affect the cells that are responsible for myelin generation and maintenance.
Anterior Cingulate Cortex
Researchers also found increases in the diameters of some of the largest axons among only this group.
They speculate that together, these changes may alter functional coupling between the cingulate cortex and subcortical structures such as the amygdala and nucleus accumbens and contribute to altered emotional processing in people who have been abused during childhood.
The researchers conclude that adversity in early life may lastingly disrupt a range of neural functions in the anterior cingulate cortex.
And while they don’t yet know where in the brain and when during development, and how, at a molecular level these effects are sufficient to have an impact on the regulation of emotions and attachment, they are now planning to explore this in further research.
Pierre-Eric Lutz, Arnaud Tanti, Alicja Gasecka, Sarah Barnett-Burns, John J. Kim, Yi Zhou, Gang G. Chen, Marina Wakid, Meghan Shaw, Daniel Almeida, Marc-Aurele Chay, Jennie Yang, Vanessa Larivière, Marie-Noël M’Boutchou, Léon C. van Kempen, Volodymyr Yerko, Josée Prud’homme, Maria Antonietta Davoli, Kathryn Vaillancourt, Jean-François Théroux, Alexandre Bramoullé, Tie-Yuan Zhang, Michael J. Meaney, Carl Ernst, Daniel Côté, Naguib Mechawar, and Gustavo Turecki Association of a History of Child Abuse With Impaired Myelination in the Anterior Cingulate Cortex: Convergent Epigenetic, Transcriptional, and Morphological Evidence American Journal of Psychiatry https://doi.org/10.1176/appi.ajp.2017.16111286