Causes of Autism

Autism is a brain disorder of unknown etiology which means, in laymans terms “We just don’t know what causes it yet.”

There are various theories, and lots of controversy around the causes of autism, and some of it is involved in the debate over just how common autism is, and whether or not theres been a sharp increase in actual cases of autism in the past ten years.

For parents, one of the most important things to know is that autism is NOT a psychological disorder.

Researchers have long since put to rest the hypothesis that autism is caused by the lack of a nurturing mother, but the belief still persists in some circles. If your child has been diagnosed with autism, rest assured that it is not because you were a bad parent.

Theres a great deal of research that strongly indicates a genetic basis for autism. Case in point, the incidence of autism in the general population is approximately 1.5 in 1000 people, yet parents who have one autistic child have a 1 in 20 chance of having another autistic child. Neurobiologists are of the opinion that autism is the most heritable of all the neurobiological conditions, in fact.

The most convincing evidence is the research done in twins. Twin studies help establish a genetic link for a condition by exploring the difference in prevalence of the condition in identical (monozygotic) and fraternal (dizygotic) twins.

If a condition is genetic in origin, the prevalence will be markedly higher in monozygotic twins, since they share the exact same chromosomes. In most twin studies that have been done for autism, the prevalence of autism is as much as 90% higher in monozygotic twins than in dizygotic twins.

Then again, the studies bring up other questions. The fact that not one of the studies showed 100% concordance in monozygotic twins suggests that there are other factors at play in the causes of autism, for instance. And other familial studies have noted common characteristics for instance, that autism is more common in families of physicists and engineers, giving rise to the term the geek syndrome to identify autism.

Environmental Factors

A number of researchers believe that there may be an environmental factor in the development of autism. Dr. Bernard Rimland, for instance, proposed in 1967 that autism may be a result of mercury and heavy metal toxicity to which some children have a genetic sensitivity. His treatment of autistic children with a gluten-free, casein-free diet and mercury chelation therapy (removal of mercury from the system) has shown some success with some children.

Other environmental factors that have been suggested to play a part are viral or bacterial infections, vaccines and thalidomide.

The Supermale Brain Theory

One interesting newer theory about the cause of autism is that it results from high levels of testosterone during fetal development. A study in England measured the testosterone level of the amniotic fluid in mothers, followed up with testing of children after birth and at four years.

They found that the babies with the highest levels of testosterone pre-birth had a smaller vocabulary and made eye contact less often at a year old, and were less socially developed at age four. The theory holds that high testosterone levels in the brain support the hyperdevelopment of male skills like analysis of systems and seeing patterns, but repress the development of female skills like communication and empathy.

Image: Day Donaldson/Flickr