Bumetanide May Reverse Imbalance Linked To Fragile X Syndrome

Chromosomal instability drives metastasis
Bumetanide can reverse an ionic imbalance in neurons that leads to hyper-excitability in mice modeling an autism-related genetic disorder, a Northwestern Medicine study indicates. The findings suggest that the sensory hypersensitivity experienced by patients with fragile X syndrome, a syndromic autism, may be caused by elevated intracellular chloride in neurons during early development, according to …