Amyloid Beta Plaque Affects Neurons Differently From Glia

Amyloid beta, the protein linked with Alzheimer’s disease, has different properties in different cell types in the brains of fruit flies, a study led by researchers at Linköping University in Sweden indicates. Although amyloid beta is highly toxic for nerve cells, it appears that certain other types of cell are unaffected by aggregates of the…

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Microglia Immune Memory Modulates Neuropathology

Inflammatory reactions can alter the brain’s immune cells in the long term — meaning that these cells have an “immunological memory.” This memory may influence the progression of neurological disorders that occur later in life, and is therefore a previously unknown factor that could influence the severity of these diseases, scientists at the German Center…

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Traumatic Brain Injury May Raise Dementia Risk

Individuals who have experienced brain injuries have a higher risk of dementia later in life, research based on a study of nearly 3 million people in Denmark suggests. Researchers identified people who’d experienced a traumatic brain injury (TBI) and those who hadn’t, and followed them up for an average of 10 years to see if…

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Fragile X Syndrome Infants Have Less Developed White Matter

Babies with the neurodevelopmental condition fragile X syndrome had less-developed white matter compared to infants that did not develop the condition, an imaging study from UNC School of Medicine researchers indicates. The work shows that there are brain differences related to the neurodevelopmental disorder established well before a diagnosis is typically made at age three…

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Nanoparticles May Damage DNA Of Developing Neurons

When cellular barriers are exposed to metal nanoparticles, cellular messengers are released that may cause damage to the DNA of developing brain cells, new research by scientists shows. The discovery, from scientists at Trinity College and the University of Bristol, may have implications for the development of potential drug targets in the treatment of neurodegenerative…

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Virtual Learning Enhances Neural Health In Adults With Autism

A clinician-driven virtual learning platform, tailored to young adults on the autism spectrum, results in improved social competency, a pilot study shows. The findings, from researchers at the Center for BrainHealth at The University of Texas at Dallas, in collaboration with co-leading authors at George Washington University and Yale, reveal that increases in socio-emotional and…

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How ISRIB Reverses Cognitive Deficits After Traumatic Brain Injury

An experimental drug, nicknamed ISRIB, completely eliminates learning and memory deficits in mice with concussions, previous research has shown. Now, Howard Hughes Medical Institute (HHMI) Investigator Peter Walter and colleagues, have provided a clearer view of how ISRIB works — by pinning together parts of a protein involved in cellular stress. Tracking how ISRIB interacts…

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Cell Therapy Instigates Neural Repair In Friedreich’s Ataxia Mice

A research group from Bristol (U.K) have established a potential cell therapy for Friedreich’s ataxia (FRDA) which managed to aid motor coordination, stimulate neural repair and even start to reverse disease pathology in a FRDA mouse model. The group transplanted healthy mouse bone marrow cells into the genetically altered FRDA mice to elicit the reparative…

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Vagus Nerve Stimulation Enhances Post-stroke Rehabilitative Training

Vagus nerve stimulation, paired with a physical therapy task, doubles long-term recovery rate relative to current therapy methods, new rodent research indicates. The study, from researchers at The University of Texas at Dallas, demonstrates a method to accelerate motor skill recovery after a stroke by helping the brain reorganize itself more quickly. A clinical trial…

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