Microglia Help Regulate Blood Flow In The Brain

Microglia help regulate blood flow and maintain the brain’s critical blood vessels, University of Virginia School of Medicine researchers have found. It is an important but previously unknown role for these immune cells that protect the brain from disease and injury. The findings1 may prove important in cognitive decline, dementia and stroke, among other conditions…

Modified Macrophage Metabolism Aids Peripheral Nerve Regeneration

Macrophages can be altered to support and speed the regeneration of peripheral nerves in mice following injury, Johns Hopkins Medicine researchers have found. The nerves outside the brain and spinal cord, known as peripheral nerves, have the capacity for regeneration, but the rate of natural renewal is so slow that many nerve injuries lead to…

More Evidence For Link Between Type II Diabetes And Alzheimer’s

Chronic hyperglycemia impairs working memory performance and alters fundamental aspects of working memory networks, a new study1 shows. The finding, from a team of University of Nevada, Las Vegas neuroscientists has strengthened the link between Type II diabetes and Alzheimer’s disease. Diabetes is a major risk factor for developing Alzheimer’s disease, but it is not…

Alpha Synuclein Is Transferred Between Microglia Through Tunneling Nanotubes

To degrade toxic proteins more rapidly, immune cells in the brain can join together to form networks when needed, a joint study of the University of Bonn, the German Center for Neurodegenerative Diseases (DZNE) and the Institut François Jacob in France shows1. However, in certain mutations that can cause Parkinson’s disease, this cooperation is impaired.…

Amyloids From The Liver May Cause Alzheimer’s Disease In The Brain

Amyloid protein produced in the liver can cause neurodegeneration in brain tissue, a new study1 by John Mamo of Curtin University, and colleagues has found. Since the protein is thought to be a key contributor to development of Alzheimer’s disease (AD), the results suggest that the liver may play an important role in the onset…

ADHD Linked To Dementia Risk Across Generations

Parents and grandparents of individuals with Attention-deficit/hyperactivity disorder were at higher risk of dementia than those with children and grandchildren without ADHD, a large study1 at Karolinska Institutet in Sweden has found. The findings suggest that there are common genetic and/or environmental contributions to the association between ADHD and dementia. Now we need further studies…

LSL60101 Reduces Cognitive Deficit In Neurodegeneration

The compound LSL60101 improved cognitive deficit and biomarkers related to Alzheimer’s disease in studies carried out with mice. The work is described in a paper1 detailing the synthesis of a new family of compounds with high affinity and selectivity for imidazoline I2 receptors, altered in the brain of patients with Alzheimer’s. The synthesis pathway of…

What Is The Subventricular Zone?

The subventricular zone is a region situated on the outside wall of each lateral ventricle of the vertebrate brain. It is present in both the embryonic and adult brain. In embryonic life, the subventricular zone (SVZ) refers to a secondary proliferative zone containing neural progenitor cells, which divide to produce neurons in the process of…