Proton Pump Inhibitor Misuse A Growing Danger

proton pump inhibitor misuse
The introduction of proton pump inhibitors (PPIs) into clinical practice has revolutionized the management of acid-related diseases. Pharmacological acid suppression has been so successful in healing peptic ulcers and managing patients with gastro-esophageal reflux disease that elective surgery for ulcer disease has been virtually abolished and anti-reflux operations are today performed only in selected patients. …

Liver Hormone FGF21 May Curb Alcohol Cravings

fgf21
FGF21, a liver hormone, may regulate alcohol consumption by acting directly on a receptor in the brain, a new study by researchers from King's College London, Imperial College London and UT Southwestern Medical Center has found. The biggest genome-wide meta-analysis and replication study ever mapped and compared the DNA of more than 105,000 light and …

Vedolizumab Immunotherapy Cures Genetic Autoimmune Enteritis

Autoimmune Enteritis
A type of autoimmune enteritis caused by a recently discovered genetic mutation has been cured using targeted immunotherapy, researchers at the Department of Biomedicine of the University of Basel and University Hospital Basel report. The results raise new possibilities for the management of diarrhea, often a side effect of melanoma treatment. Immunodeficiencies can arise due …

Aspartame May Block Weight Loss By Inhibiting Gut Enzyme

aspartame drinks
A possible explanation of why using the sugar substitute aspartame might not promote weight loss has been found by researchers at Massachusetts General Hospital. The researchers showed how the aspartame breakdown product phenylalanine interferes with the action of an enzyme previously shown to prevent metabolic syndrome - a group of symptoms associated with type 2 …

Neural Stem Cells Found In The Membranes Covering The Brain

neural sem cells
Unexpected cells have been discovered in the protective membranes that enclose the brain, the so called meninges. These neural progenitors, stem cells that differentiate into different kinds of neurons , are produced during embryonic development. The cross-domain study, directed by professor Peter Carmeliet of the Flanders Institute for Biotechnology (VIB - KU Leuven), shows that …

ALK1 Facilitates LDL Cholesterol’s Transport Within Cells

blood clot
Arteries clog with fats and cholesterol when certain proteins in the body, known as lipoproteins, combine with and transport fats in the blood to cells. Scientists have long believed that the Low-density lipoprotein (LDL) receptor molecule was responsible for the transport of LDL within cells. But the fact that some individuals who lack the LDL …

Odds Of Longevity Higher In Women With Later First Childbirth Age

mother first time childbirth
Over the past four decades the average age for a woman giving birth for the first time has risen in the United States, driven by factors like education and career. A new study by researchers at University of California San Diego School of Medicine found that women choosing to become first-time mothers later in life …

Tau Phosphorylation Curbs Amyloid Beta Toxicity In Alzheimers

tau phosphorylation
A protein called kinase p38γ, which is lost as Alzheimer's disease progresses, has been identified by researchers at the University of New South Wales and Neuroscience Research Australia. When they reintroduced the protein into the brains of mice, it was shown to have a protective effect against memory deficits associated with the disease. The study …