Merck’s therapeutic antibody Pembrolizumab, marketed as Keytruda, has won U.S. Food and Drug Administration approval as a treatment for refractory classical Hodgkin lymphoma. The approval was based on data in 210 patients from the KEYNOTE-087 trial. The clinical trial showed an overall response rate with KEYTRUDA (200 mg every three…Continue readingPembrolizumab Gets FDA Approval for Hodgkin Lymphoma Indication
Although people diagnosed with cystic fibrosis are surviving longer than ever before, their lifespan is nearly 10 years longer in Canada than the United States, reports new research. Cystic fibrosis is a genetic disease that affects the lungs, pancreas, liver, intestines, sinuses, and sex organs. Cystic fibrosis causes your mucus…Continue readingCystic Fibrosis Patients In Canada Outlive US Counterparts
The inhabitants of Rjukan in southern Norway have a complex relationship with the sun. “More than other places I’ve lived, they like to talk about the sun: when it’s coming back, if it’s a long time since they’ve seen the sun,” says artist Martin Andersen. “They’re a little obsessed with…Continue readingIs The Winter Darkness Really Making Me Sad?
Studies dating back to the 1800s have found that suicides peak in the spring and are lowest in winter. “If we take winter as a baseline, then there’s a 20–60 per cent higher suicide rate during spring,” says Fotis Papadopoulos, a professor of psychiatry at Uppsala University in Sweden, who…Continue readingThe Surprising Link Between Sunshine And Suicide
Moesin, a membrane-domain organizing protein, controls regulatory T cell (Treg) function as well as the abundance and stability of transforming growth factor-beta (TGF-beta) receptors on the surface of cells, preclinical research shows. The protein is a potential therapeutic target for cancer immunotherapy, Medical University of South Carolina (MUSC) investigators report.…Continue readingMoesin Regulates Cancer Immunity, May Be Immunotherapy Target
B vitamins might play a role in reducing the impact of air pollution on the epigenome, a new study by researchers at Columbia University has shown. The study is the first to lay out a path of research for developing interventions to prevent or minimize the adverse effects of air…Continue readingVitamin B May Reduce Air Pollution Epigenetic Effects
A new way to restore antibiotic susceptibility in multidrug-resistant (MDR) Klebsiella pneumoniae and Escherichia coli strains has been discovered by researchers at the University of Copenhagen and Ross University School. Klebsiella pneumoniae is a main cause of fatal lung and bloodstream infections worldwide. A novel approach to identify genes that…Continue readingRestoring Antibiotic Susceptibility In Antibiotic Resistant Superbugs